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. 2014 May 23;9:2581–2595. doi: 10.2147/IJN.S63472

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© 2014 Dumont et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Molecular MRI-based detection of PBT cells using biofunctionalized Prussian blue nanoparticles. (A) T1-weighted and T2-weighted contrast enhancement in phantoms comprised of a fixed number of BSG D10 treated with MnPB-A488-ANG2 (n=6), MnPB-A488-AbC (n=3), or MnPB-A488 (no antibody, triplicate). (B) Normalized fluorescence signal intensity (au) for BSG D10 treated with ANG2, AbC, and no antibody-modified MnPB-A488. **P<0.05.

Abbreviations: MnPB, manganese-containing Prussian blue; A488, avidin-Alexa Fluor 488; ANG2, anti-neuron-glial antigen 2; AbC, eotaxin antibody; BSG, brainstem glioma; T1W, T1-weighted; T2W, T2-weighted; PBT, pediatric brain tumor; au, arbitrary units; Ab, antibody; MRI, magnetic resonance imaging.