Table 1.
Effect of alkalization pH
| pH | Fe concentration (mM)
|
Encapsulation efficiency (%) | Final lipid content (mM) | Drug loading (mol Fe/mol lipid) | |||
|---|---|---|---|---|---|---|---|
| Before alkalization
|
After alkalization
|
||||||
| Feb | Fe(t) | Fe(f) | Fe(c) | ||||
| 13 | 34.2±0.5 | 18.3±1.2 | 1.5±0.8 | 16.8±0.4 | 11.1±0.3 | 18.1±0.4 | 0.92±0.02 |
| 12 | 35.0±0.7 | 30.8±1.8 | 4.3±2.5 | 26.5±1.2 | 17.7±0.8 | 19.1±0.4 | 1.39±0.04 |
| 11 | 34.0±1.8 | 30.9±1.3 | 16.0±1.3 | 14.9±0.5 | 9.9±0.3 | 19.1±0.4 | 0.78±0.04 |
| 10 | 33.6±1.3 | 30.4±0.8 | 18.2±0.7 | 12.1±0.5 | 8.1±0.4 | 19.2±0.3 | 0.63±0.02 |
Note: n=3.
Abbreviations: Feb, the amount of iron ions in liposomes before alkalization; Fe(t), the amount of total iron in the liposomes after alkalization; Fe(f), the amount of free iron ions in the liposomes after alkalization; Fe(c), the amount of iron-oxide cores in magnetoliposomes.