Table 4.
Effect of initial iron-ion concentration
| Fea (mM) | Fe concentration (mM)
|
Encapsulation efficiency (%) | Final lipid content (mM) | Drug loading (mol Fe/mol lipid) | |||
|---|---|---|---|---|---|---|---|
| Before alkalization
|
After alkalization
|
||||||
| Feb | Fe(t) | Fe(f) | Fe(c) | ||||
| 600 | 37.6±2.7 | 19.4±2.1 | 1.2±0.6 | 18.2±1.5 | 3.0±0.3 | 16.0±0.2 | 1.14±0.09 |
| 300 | 35.5±1.1 | 21.6±1.1 | 1.2±0.3 | 20.4±1.0 | 6.8±0.3 | 16.9±0.2 | 1.21±0.05 |
| 150 | 34.6±0.6 | 28.5±0.5 | 0.8±0.2 | 27.7±0.4 | 18.5±0.3 | 17.5±0.6 | 1.58±0.04 |
| 75 | 17.9±0.4 | 16.9±0.3 | 0.2±0.1 | 16.8±0.4 | 22.3±0.5 | 18.7±0.2 | 0.90±0.01 |
Note: n=3.
Abbreviations: Fea, the initial concentration of iron ions added in the system; Feb, the amount of iron ions in liposomes before alkalization; Fe(t), the amount of total iron in the liposomes after alkalization; Fe(f), the amount of free iron ions in the liposomes after alkalization; Fe(c), the amount of iron-oxide cores in magnetoliposomes.