Table 3.
Top 50 genes upregulated (RBC1023 + STAU group versus STAU group)
| Gene symbol | Fold-change (RBC1023 + STAU vs STAU) | P-value (RBC1023 + STAU vs STAU) | Function |
|---|---|---|---|
| Ly6a | 4.94653 | 5.35E-06 | Lymphocyte antigen 6 complex |
| Lrrn4cl | 4.09678 | 2.17E-05 | Function unknown |
| Egr1 | 4.0647 | 4.13E-05 | Differentiation and mitogenesis |
| Plat | 3.90703 | 0.00025859 | Plasminogen activator |
| Bdkrb1 | 3.89931 | 2.63E-06 | Inflammatory responses |
| Rhob | 3.5974 | 0.000108495 | Ras signaling cascade |
| Nek2 | 3.42607 | 6.47E-06 | Serine/threonine-protein kinase that is involved in mitotic regulation |
| Serpinb1a | 3.41146 | 3.16E-05 | Regulates the activity of the neutrophil proteases elastase |
| Taok1 | 3.35134 | 0.00379721 | Serine/threonine-protein kinase |
| Bhlhe40 | 3.29921 | 0.000687826 | Cell differentiation |
| Angptl2 | 3.28147 | 6.37E-05 | Growth factors |
| 4930547N16Rik | 3.24155 | 7.27E-06 | Function unknown |
| Plxna2 | 3.20986 | 3.55E-06 | Nervous system development |
| Aurka | 3.17042 | 0.00014278 | Serine/threonine-protein kinase 6 |
| Tceal1 | 3.14666 | 1.88E-05 | Transcriptional regulation |
| Il18 | 3.07789 | 8.13E-05 | A proinflammatory cytokine |
| Tacr2 | 3.04967 | 5.85E-05 | Receptors for tachykinins |
| Ccnb1 | 3.00447 | 1.19E-05 | Control of the cell cycle at the G2/M (mitosis) transition |
| Hist1h1c | 2.9718 | 2.15E-05 | Chromatin remodeling, nucleosome spacing and DNA methylation |
| Mfsd6 | 2.96238 | 4.17E-06 | Function unknown |
| Cdc25c | 2.95929 | 8.77E-06 | Cell mitotic control |
| Arhgef12 | 2.94683 | 0.00060089 | Stimulate Rho-dependent signals |
| Tnfaip6 | 2.92751 | 2.48E-05 | Involved in cell-cell and cell-matrix interactions |
| Depdc1a | 2.92024 | 5.13E-05 | Transcriptional regulation |
| Cep55 | 2.83691 | 4.68E-06 | Mitotic exit and cytokinesis |
| Gas2l3 | 2.81642 | 8.16E-07 | Promote and stabilize the formation of the actin and microtubule network |
| Ttll7 | 2.80163 | 3.77E-05 | Neurite growth |
| Mastl | 2.79123 | 3.11E-06 | A regulator of mitosis entry and maintenance |
| Cdkn3 | 2.75997 | 4.81E-06 | Cell cycle regulation |
| Kif2c | 2.73935 | 4.82E-05 | Regulates the turnover of microtubules during mitosis |
| Anxa8 | 2.72379 | 0.000119099 | Involved in the blood coagulation cascade |
| Cyp39a1 | 2.71735 | 9.70E-06 | Involved in drug metabolism and synthesis of cholesterol, steroids |
| Bend6 | 2.69474 | 0.000311133 | Function unknown |
| Hyls1 | 2.69324 | 1.54E-06 | Required for the formation of cilia |
| 6720463M24Rik | 2.66567 | 7.35E-06 | Function unknown |
| Cenpe | 2.65857 | 8.09E-07 | Essential for the maintenance of chromosomal stability |
| Adamtsl5 | 2.65327 | 2.33E-06 | Function unknown |
| Tlr4 | 2.64933 | 4.06E-05 | Mediate the innate immune response to LPS |
| Dusp6 | 2.61857 | 0.000175186 | Inactivates MAP kinases |
| Kif20b | 2.60411 | 0.000105112 | Required for completion of cytokinesis |
| Stxbp4 | 2.60053 | 0.0106744 | Plays a role in the translocation of transport vesicles |
| Aldh3a1 | 2.59577 | 5.93E-05 | The metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid |
| Prc1 | 2.58871 | 1.85E-05 | Involved in cytokinesis |
| Ndc80 | 2.58587 | 0.000245121 | Required for chromosome segregation and spindle checkpoint activity |
| Glmn | 2.58467 | 0.00018307 | Essential for normal development of the vasculature |
| Plk1 | 2.54604 | 2.21E-05 | Regulators of cell cycle progression, mitosis, cytokinesis, and the DNA damage |
| Atf7ip2 | 2.54547 | 1.85E-05 | Modulates transcription regulation and chromatin formation |
| Mir15b | 2.53671 | 0.00251676 | Involved in post-transcriptional regulation of gene expression |
| Suox | 2.53666 | 9.13E-05 | Catalyzes the oxidation of sulfite to sulfate |
| Serpinb9b | 2.53635 | 0.000123141 | Inhibits the activity of the effector molecule granzyme |
Abbreviation: STAU, staurosporine.