Table S1.
Molecular functions of the top 200 upregulated and downregulated clustering genes in the heat map
| Ref seq | Gene symbol | P-value (observed group) | Molecular function |
|---|---|---|---|
| 1. NM_010655 | Kpna2 | 5.05E-08 | Nuclear protein import |
| 2. NM_173752 | 1110067D22Rik | 6.85E-08 | Function unknown |
| 3. NM_025415 | Cks2 | 2.15E-07 | Binds to cyclin dependent kinases |
| 4. NM_010655 | Kpna2 | 2.90E-07 | Nuclear protein import |
| 5. NM_001081127 | Adamts14 | 5.96E-07 | Metallopeptidase |
| 6. NM_007960 | Etv1 | 6.49E-07 | Transcriptional activator |
| 7. NM_019752 | Htra2 | 8.23E-07 | Caspase activation |
| 8. NM_175149 | 2310022B05Rik | 9.86E-07 | Function unknown |
| 9. NM_011158 | Prkar2b | 1.19E-06 | cAMP signaling |
| 10. NM_029074 | Tmem188 | 1.44E-06 | Protein phosphatase |
| 11. – | 1.52E-06 | N/A | |
| 12. NM_028607 | Bloc1s2 | 1.57E-06 | Biogenesis of lysosome |
| 13. NM_010358 | Gstm1 | 2.17E-06 | Glutathione S-transferases |
| 14. NM_172757 | Heatr3 | 2.51E-06 | Function unknown |
| 15. NM_008036 | Fosb | 3.03E-06 | Form the transcription factor complex AP-1 |
| 16. NM_145692 | Ppp1r42 | 3.03E-06 | Regulates phosphatase activity |
| 17. NM_009178 | St3gal4 | 3.24E-06 | Protein glycosylation |
| 18. NM_198092 | Usp2 | 3.36E-06 | Hydrolase that deubiquitinates polyubiquitinated target proteins |
| 19. ENSMUST00000000001 | Gnai3 | 3.69E-06 | Modulator in various transmembrane signaling systems |
| 20. NM_013496 | Crabp1 | 3.79E-06 | Involved in retinoic acid-mediated differentiation and proliferation processes |
| 21. – | 4.39E-06 | N/A | |
| 22. NM_022995 | Pmepa1 | 4.56E-06 | Involved in down-regulation of the androgen receptor |
| 23. NM_001048192 | Agbl5 | 4.73E-06 | Mediates tubulin deglutamylation |
| 24. NM_011654 | Tuba1b | 4.92E-06 | Interaction with PI3KR1 |
| 25. NM_029556 | Clybl | 4.95E-06 | Citrate lyase |
| 26. NM_178942 | Il17rc | 4.99E-06 | Cytokine signaling |
| 27. NM_008495 | Lgals1 | 5.13E-06 | Regulates cell proliferation |
| 28. NM_009672 | Anp32a | 5.18E-06 | Cell proliferation and differentiation |
| 29. NM_033595 | Pcdhga12 | 5.32E-06 | Involved in the establishment and maintenance of specific neuronal connections in the brain |
| 30. NM_007951 | Erh | 5.36E-06 | Involved in the establishment of specific neuronal connections in the brain |
| 31. ENSMUST00000066352 | Ptrh1 | 5.47E-06 | tRNA hydrolase |
| 32. NM_010918 | Nktr | 5.68E-06 | Involved in the function of NK cells |
| 33. NM_013726 | Dbf4 | 5.81E-06 | Plays a central role in DNA replication and cell proliferation |
| 34. NM_031408 | Gigyf1 | 5.85E-06 | Regulates tyrosine kinase receptor signaling |
| 35. NM_011056 | Pde4d | 5.86E-06 | Degrade cAMP |
| 36. ENSMUST00000029316 | Exosc8 | 6.09E-06 | Participates in cellular RNA processing and degradation events |
| 37. NM_019511 | Ramp3 | 6.55E-06 | Receptor for adrenomedullin |
| 38. NR_033813 | Dlk1 | 6.72E-06 | Plays a role in neuroendocrine differentiation |
| 39. – | 6.73E-06 | N/A | |
| 40. NM_012043 | Islr | 6.93E-06 | Function unknown |
| 41. NM_027030 | Dcps | 7.14E-06 | Decapping scavenger enzyme |
| 42. – | 7.55E-06 | N/A | |
| 43. NM_172574 | Pqlc3 | 7.74E-06 | Protein coding |
| 44. NM_025415 | Cks2 | 8.20E-06 | Involved in cyclin dependent kinase function |
| 45. NM_010171 | F3 | 8.68E-06 | Coagulation factor III |
| 46. NM_026268 | Dusp6 | 8.95E-06 | Inactivates MAP kinases |
| 47. NM_016762 | Matn2 | 9.13E-06 | Formation of filamentous networks |
| 48. NM_144829 | Aarsd1 | 1.01E-05 | tRNA synthetase |
| 49. – | 1.04E-05 | N/A | |
| 50. NM_027859 | Rnf215 | 1.05E-05 | Ring finger protein |
| 51. NM_009154 | Sema5a | 1.05E-05 | Involved in axonal guidance during neural development |
| 52. NM_001033165 | Dnajc25 | 1.07E-05 | Function unknown |
| 53. NM_007476 | Arf1 | 1.19E-05 | Vesicular trafficking |
| 54. NM_029701 | Spcs3 | 1.21E-05 | Removes signal peptides from nascent proteins |
| 55. AK139984 | Gm10616 | 1.21E-05 | N/A |
| 56. NM_026815 | Upk1a | 1.22E-05 | Mediates signal transduction events |
| 57. NM_172563 | Hlf | 1.22E-05 | Function unknown |
| 58. NM_009193 | Slbp | 1.28E-05 | Involved in the histone pre-mRNA processing |
| 59. NM_007960 | Etv1 | 1.28E-05 | Transcriptional activator |
| 60. NM_001081636 | Ccnd3 | 1.29E-05 | Cell cycle regulation |
| 61. NM_028770 | Krt80 | 1.30E-05 | Major structural fibers of cells |
| 62. NM_016750 | H2afz | 1.31E-05 | Nucleosome structure protein |
| 63. – | 1.37E-05 | N/A | |
| 64. NM_011366 | Sorbs3 | 1.39E-05 | Activation of JNK |
| 65. NR_028560 | Scarna17 | 1.41E-05 | Function unknown |
| 66. NR_028560 | Scarna17 | 1.41E-05 | Function unknown |
| 67. NM_008008 | Fgf7 | 1.42E-05 | Regulation of embryonic development, cell proliferation and cell differentiation |
| 68. NM_027911 | Raver1 | 1.44E-05 | Modulate regulated alternative splicing events |
| 69. NM_019840 | Pde4b | 1.44E-05 | Hydrolyzes cAMP |
| 70. NM_011873 | Dazap2 | 1.46E-05 | Cell signaling and transcription regulation |
| 71. NM_025982 | Tspan31 | 1.46E-05 | Regulation of cell development, activation, growth and motility |
| 72. NM_010655 | Kpna2 | 1.50E-05 | Nuclear protein import |
| 73. NM_008891 | Pnn | 1.50E-05 | Transcriptional activator |
| 74. NM_008193 | Guk1 | 1.51E-05 | Essential for recycling GMP |
| 75. NM_198658 | Nr1h5 | 1.54E-05 | Function unknown |
| 76. NM_001242364 | Fam160a2 | 1.56E-05 | Promotes vesicle trafficking |
| 77. NM_021605 | Nek7 | 1.60E-05 | Mitotic cell cycle progression |
| 78. NM_009387 | Tk1 | 1.62E-05 | Thymidine kinase |
| 79. NM_025281 | Lyar | 1.64E-05 | Function unknown |
| 80. NM_172458 | Zfp871 | 1.64E-05 | Function unknown |
| 81. NM_177390 | Myo1d | 1.68E-05 | Involved in intracellular movements |
| 82. NM_153195 | Fbxo7 | 1.71E-05 | A negative regulator of NF-kappaB signaling |
| 83. NM_144549 | Trib1 | 1.77E-05 | Interacts with MAPK kinases and regulates activation of MAP kinases |
| 84. NM_023117 | Cdc25b | 1.80E-05 | Dephosphorylates CDK1 and stimulates its kinase activity |
| 85. NR_028480 | Gm12238 | 1.84E-05 | Function unknown |
| 86. NM_011664 | Ubb | 1.86E-05 | Ubiquitination and protein degradation |
| 87. NM_008037 | Fosl2 | 1.88E-05 | Forming the transcription factor complex AP-1 |
| 88. – | 1.88E-05 | N/A | |
| 89. NM_022312 | Tnr | 1.88E-05 | Mediates inhibition of cell adhesion and neurite outgrowth |
| 90. NM_011693 | Vcam1 | 1.89E-05 | Mediates leukocyte-endothelial cell adhesion and signal transduction |
| 91. NM_145706 | Nup43 | 1.89E-05 | Required for microtubule attachment, mitotic progression and chromosome segregation |
| 92. NM_012003 | Cops7a | 1.90E-05 | Involved in various cellular and developmental processes |
| 93. NM_145823 | Pitpnc1 | 1.91E-05 | Involved in cell signaling and lipid metabolism |
| 94. NM_008801 | Pde6d | 1.94E-05 | Involved in cellular signal transduction |
| 95. NR_028528 | Snord57 | 1.95E-05 | Small nucleolar RNA |
| 96. NM_008086 | Gas1 | 1.96E-05 | Involved in growth suppression |
| 97. NR_004445 | Snord22 | 2.01E-05 | Small nucleolar RNA |
| 98. NM_001113486 | 2.01E-05 | N/A | |
| 99. NM_026667 | Fam114a1 | 2.06E-05 | Plays a role in neuronal cell development |
| 100. NM_001166065 | Gcnt4 | 2.09E-05 | Glycosyltransferase |
| 101. NM_025415 | Cks2 | 2.11E-05 | Binds to cyclin dependent kinases |
| 102. NM_001081229 | Tsc22d2 | 2.12E-05 | Function unknown |
| 103. NM_011923 | Angptl2 | 2.12E-05 | Induces sprouting in endothelial cells |
| 104. NM_011664 | Ubb | 2.15E-05 | Ubiquitination and protein degradation |
| 105. ENSMUST00000105363 | Gamt | 2.16E-05 | Methyltransferase |
| 106. NM_011654 | Tuba1b | 2.16E-05 | Interaction with PI3KR1 |
| 107. NM_001159288 | Morc2a | 2.18E-05 | Transcriptional repressor |
| 108. NM_010560 | Il6st | 2.30E-05 | Signal-transducing molecule |
| 109. – | 2.31E-05 | N/A | |
| 110. NM_178403 | Pus7 | 2.32E-05 | Catalyzes pseudouridylation |
| 111. NM_001030307 | Dkc1 | 2.34E-05 | Required for ribosome biogenesis and telomere maintenance |
| 112. NM_008197 | H1f0 | 2.35E-05 | Required for the condensation of nucleosome chains into higher-order structures |
| 113. NM_028156 | 1700001P01Rik | 2.40E-05 | Function unknown |
| 114. NM_008871 | Serpine1 | 2.45E-05 | Serine protease inhibitor |
| 115. L08651 | Rpl29 | 2.46E-05 | Ribosomal protein |
| 116. – | 2.48E-05 | N/A | |
| 117. NM_001198985 | Tjp2 | 2.50E-05 | Plays a role in tight junctions and adherens junctions |
| 118. NM_027349 | Rbm25 | 2.55E-05 | A regulator of alternative pre-mRNA splicing |
| 119. NM_001110310 | Snx12 | 2.66E-05 | Involved in several stages of intracellular trafficking |
| 120. NM_178615 | Rgmb | 2.79E-05 | Promotes neuronal adhesion |
| 121. NM_010234 | Fos | 2.79E-05 | Forms the transcription factor complex AP-1 |
| 122. NM_011812 | Fbln5 | 2.82E-05 | Plays a role in vascular development and remodeling |
| 123. – | 2.83E-05 | N/A | |
| 124. NM_001013762 | Gm4952 | 2.86E-05 | Function unknown |
| 125. NM_001190466 | Dact1 | 2.87E-05 | Involved in regulation of intracellular signaling pathways |
| 126. NM_029999 | Lbh | 2.94E-05 | Involved in MAP kinase signaling pathway |
| 127. NM_010026 | Asap1 | 2.94E-05 | Involved in the differentiation of fibroblasts into adipocytes |
| 128. – | 2.98E-05 | N/A | |
| 129. ENSMUST00000012348 | Gstm2 | 2.99E-05 | Glutathione S-transferase |
| 130. NM_001080129 | Tmpo | 2.99E-05 | Helps maintain the structural organization of the nuclear envelope |
| 131. NM_011898 | Spry4 | 3.06E-05 | Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway |
| 132. NM_026115 | Hat1 | 3.17E-05 | Plays a role in DNA repair |
| 133. NM_178591 | Nrg1 | 3.18E-05 | Plays critical roles in the growth and development of multiple organ systems |
| 134. NR_046144 | Rn5s20 | 3.19E-05 | Required for transcription |
| 135. NM_145354 | Nsun2 | 3.20E-05 | RNA methyltransferase |
| 136. NM_001111059 | Cd34 | 3.28E-05 | Plays a role in the attachment of stem cells to stromal cells |
| 137. NM_001204233 | Spp1 | 3.29E-05 | Involved in enhancing production of interferon-gamma |
| 138. NM_026864 | Rasl11a | 3.30E-05 | Ras signaling |
| 139. NM_133714 | Kansl2 | 3.32E-05 | Involved in acetylation of nucleosomal histone H4 |
| 140. NM_021389 | Sh3kbp1 | 3.36E-05 | Involved in apoptosis, cytoskeletal rearrangement, cell adhesion |
| 141. – | 3.37E-05 | N/A | |
| 142. NM_009609 | Actg1 | 3.38E-05 | Involved in various types of cell motility |
| 143. NM_011859 | Osr1 | 3.38E-05 | Transcription factor |
| 144. NM_010256 | Gart | 3.43E-05 | Required for De novo purine biosynthesis |
| 145. NM_011435 | Sod3 | 3.44E-05 | Antioxidant enzymes |
| 146. – | 3.46E-05 | N/A | |
| 147. – | 3.47E-05 | N/A | |
| 148. NM_178604 | Txnl4a | 3.48E-05 | Essential role in pre-mRNA splicing |
| 149. BC089624 | Rpl7a | 3.53E-05 | Catalyzes protein synthesis |
| 150. NM_008047 | Fstl1 | 3.54E-05 | Modulates the action of some growth factors |
| 151. NM_207161 | BC048355 | 3.58E-05 | Function unknown |
| 152. NM_009626 | Adh7 | 3.70E-05 | Required for synthesis of retinoic acid |
| 153. NM_172301 | Ccnb1 | 3.71E-05 | A regulatory protein involved in mitosis |
| 154. NM_013543 | H2-Ke6 | 3.73E-05 | Plays a role in biosynthesis of fatty acids in mitochondria |
| 155. NM_001081277 | Ak5 | 3.74E-05 | Involved in regulating the adenine nucleotide composition |
| 156. NM_181390 | Mustn1 | 3.79E-05 | Involved in the development and regeneration of the musculoskeletal system |
| 157. NM_009498 | Vamp3 | 3.84E-05 | Involved in vesicular transport from the late endosomes to the trans-Golgi network |
| 158. NM_027722 | Nudt4 | 3.86E-05 | Plays a role in signal transduction |
| 159. NM_022324 | Sdf2l1 | 3.87E-05 | Function unknown |
| 160. NM_007621 | Cbr2 | 3.88E-05 | Plays a role in the uronate cycle of glucose metabolism |
| 161. NM_026369 | Arpc5 | 4.07E-05 | Involved in regulation of actin polymerization |
| 162. AK079043 | Gm9908 | 4.09E-05 | Function unknown |
| 163. NM_011415 | Snai2 | 4.10E-05 | Transcriptional repressor |
| 164. NM_008027 | Flot1 | 4.13E-05 | Involved in vesicular trafficking and signal transduction |
| 165. NM_011452 | Serpinb9b | 4.14E-05 | Granzyme B inhibitor |
| 166. NM_001100454 | Wfikkn1 | 4.18E-05 | Protease inhibitor |
| 167. NM_016750 | H2afz | 4.22E-05 | Plays a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability |
| 168. NM_028626 | Mcee | 4.29E-05 | Function unknown |
| 169. NM_010729 | Loxl1 | 4.32E-05 | Plays roles in developmental regulation, senescence, tumor suppression |
| 170. NR_034052 | Snora2b | 4.33E-05 | Small nucleolar RNA |
| 171. NM_146151 | Tesk2 | 4.35E-05 | Plays an important role in spermatogenesis |
| 172. NM_019571 | Tspan5 | 4.36E-05 | Mediates signal transduction events |
| 173. – | 4.44E-05 | N/A | |
| 174. NM_011297 | Rps24 | 4.48E-05 | Required for processing of pre-rRNA |
| 175. NR_004432 | Rnu12 | 4.49E-05 | RNA gene |
| 176. NM_007436 | Aldh3a1 | 4.50E-05 | Involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation |
| 177. NM_009504 | Vdr | 4.50E-05 | Nuclear hormone receptor |
| 178. NM_029645 | Gatc | 4.59E-05 | Allows the formation of correctly charged Gln-tRNA in the mitochondria |
| 179. NM_145360 | Idi1 | 4.59E-05 | Required for the synthesis of farnesyl diphosphate and cholesterol |
| 180. NM_053273 | Ttyh2 | 4.59E-05 | Involved in cell proliferation and cell aggregation |
| 181. NM_173756 | Lin52 | 4.61E-05 | Represses cell cycle-dependent genes |
| 182. ENSMUST00000064795 | Egr1 | 4.61E-05 | Activates the transcription of target genes whose products are required for mitogenesis and differentiation |
| 183. NM_010308 | Gnao1 | 4.64E-05 | Transducers in transmembrane signaling systems |
| 184. NM_008304 | Sdc2 | 4.66E-05 | Mediates cell binding, cell signaling, and cytoskeletal organization |
| 185. NM_029809 | 2310014L17Rik | 4.66E-05 | Function unknown |
| 186. NM_009830 | Ccne2 | 4.68E-05 | Essential for the control of the cell cycle at the late G1 and early S phase |
| 187. ENSMUST00000067692 | Rad51c | 4.71E-05 | Essential for the homologous recombination pathway of DNA repair |
| 188. NM_010219 | Fkbp4 | 4.76E-05 | Plays a role in the intracellular trafficking |
| 189. NM_172590 | Wdr41 | 4.78E-05 | Function unknown |
| 190. NM_177370 | Rhbdd3 | 4.81E-05 | Function unknown |
| 191. ENSMUST00000027009 | Casp12 | 4.83E-05 | Reduces activation of NF-kappa-B in response to TNF |
| 192. NM_021504 | Ngly1 | 4.90E-05 | Plays a role in the proteasome-mediated degradation of misfolded glycoproteins |
| 193. NM_146206 | Tpcn2 | 4.98E-05 | Involved in smooth muscle contraction |
| 194. NM_172784 | Lrp11 | 5.01E-05 | Function unknown |
| 195. NM_018773 | Skap2 | 5.02E-05 | Plays a role in src signaling pathway |
| 196. NM_028234 | Rbm33 | 5.06E-05 | Function unknown |
| 197. ENSMUST00000097772 | Il1rl1 | 5.18E-05 | Involved in helper T cell function |
| 198. NM_023871 | Set | 5.24E-05 | Involved in apoptosis, transcription, nucleosome assembly and histone chaperoning |
| 199. NM_007413 | Adora2b | 5.29E-05 | Involved in axon elongation |
| 200. NM_007713 | Clk3 | 5.30E-05 | Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates |
Abbreviation: N/A, not available.