Table 1.
Trials and titles
| Trial | Title | Registration (if available) |
|---|---|---|
| ACCEPT-D | Aspirin and simvastatin combination for cardiovascular events prevention trial in diabetes | ISRCTN48110081 |
| ACCOMPLISH | Avoiding cardiovascular events through combination therapy in patients living with systolic hypertension | NCT00170950 |
| ACCORD | Action to control cardiovascular risk in diabetes | NCT00000620 |
| ACE | Acarbose cardiovascular evaluation trial | NCT00829660 |
| ADVANCE | Action in diabetes and vascular disease: Preterax and Diamicron – modified release controlled evaluation | NCT00145925 |
| AleCardio | A study with aleglitazar in patients with a recent acute coronary syndrome and type 2 diabetes mellitus | NCT01042769 |
| AlePrevent | A study of aleglitazar in patients with stable cardiovascular disease and glucose Abnormalities | NCT01715818 |
| ALLHAT | Antihypertensive and lipid-lowering treatment to prevent heart attack trial | NCT00000542 |
| ASCEND | A study of cardiovascular events in diabetes | NCT00135226 |
| CANVAS | Canagliflozin cardiovascular assessment study | NCT01032629 |
| CARMELINA | Cardiovascular and renal microvascular outcome study with linagliptin in patients with type 2 diabetes mellitus at high vascular risk | NCT01897532 |
| CAROLINA | Cardiovascular outcome study of linagliptin versus glimepiride in patients with type 2 diabetes | NCT01243424 |
| DCCT | Diabetes control and complications trial | NCT00360815 |
| DECLARE-TIMI 58 | Multicenter trial to evaluate the effect of dapagliflozin on the incidence of cardiovascular events | NCT01730534 |
| EDIC | Epidemiology of diabetes interventions and complications | NCT00360893 |
| ELIXA | Evaluation of cardiovascular outcomes in patients with type 2 diabetes after acute coronary syndrome during treatment with AVE 0010 (lixisenatide) | NCT01147250 |
| EMPA-REG OUTCOME | Empagliflozin cardiovascular outcome event trial | NCT01131676 |
| EXAMINE | Examination of cardiovascular outcomes with alogliptin versus standard of care in patients with type 2 diabetes mellitus and acute coronary syndrome | NCT00968708 |
| EXSCEL | Exenatide study of cardiovascular event lowering trial | NCT01144338 |
| GRAND 306 | Study of tak-875 in adults with type 2 diabetes and cardiovascular disease or risk factors for cardiovascular disease | NCT01609582 |
| LEADER | Liraglutide effect and action in diabetes: evaluation of cardiovascular outcome results – a long term evaluation | NCT01179048 |
| Look AHEAD | Look AHEAD: action for health in diabetes | NCT00017953 |
| MRFIT | Multiple risk factor intervention trial | NCT00000487 |
| ONTARGET | Ongoing telmisartan alone and in combination with ramipril global endpoint trial | NCT00153101 |
| ORIGIN | Outcome reduction with initial glargine intervention | NCT00069784 |
| PLATO | The platelet inhibition and patient outcomes trial | NCT00391872 |
| REWIND | Researching cardiovascular events with a weekly incretin in diabetes | NCT01394952 |
| SAVOR-TIMI 53 | Saxagliptin assessment of vascular outcomes recorded in patients with diabetes mellitus – thrombolysis in myocardial infarction 53 study | NCT01107886 |
| Steno-2 | Intensified multifactorial intervention in patients with type 2 diabetes and microalbuminuria | NCT00320008 |
| SUSTAIN 6 | Trial to evaluate cardiovascular and other long-term outcomes with semaglutide in subjects with type 2 diabetes | NCT01720446 |
| TECOS | Trial evaluating cardiovascular outcomes with sitagliptin | NCT00790205 |
| T-emerge 8 | A study of taspoglutide in patients with inadequately controlled diabetes mellitus type 2 and cardiovascular disease | NCT01018173 |
| TIDE | Thiazolidinedione intervention with vitamin D intervention study | NCT00879970 |
| TOSCA IT | Thiazolidinediones or sulphonylureas and cardiovascular accidents intervention trial | NCT00700856 |
| TRITON-TIMI 38 | Trial to assess improvement in therapeutic outcomes by optimizing platelet inhibition with prasugrel – thrombolysis in myocardial infarction | NCT00097591 |
| UKPDS | United Kingdom prospective diabetes study | |
| VADT | Veterans Affairs and diabetes trial | NCT00032487 |