Table 1. IPD serotypes from Pakistan by age group and specimen source, 2005–2013.
| Age group and syndrome | Source | Number of cases | Serotypes (n) | Proportion of serotypes included in PCV-10* (%) | Proportion of serotypes included in PCV-13 (%) | ||
| 0–59 months | |||||||
| Meningitis | CSF | 72 | 47/72 (65.3%) | 48/72 (66.7%) | |||
| 13 (2005–6) | 19F (4), 18A/B/C/F (2), 11A/D (2), 9V/A (1), 15B/C (1), 22A/F (1), 1 (1), NT†(1) | 8/13 (61.5%) | 8/13 (61.5%) | ||||
| 59 (2009–13) | 18A/B/C/F (11), 14 (7), 19F (2), 23B (6), 12F/A/44/46 (6), 5 (4), 9V/A (2), 1(1), 15B/C (1), 10A (2), 6A/B/C (2), 4 (2), 23F(2), 19A (1), 17 (1), 8 (1), 9N/L (1), 24A/B/F (1), 33F/A/37 (1), 35B (1), NT† (4) | 39/59 (66.1%) | 40/59 (67.8%) | ||||
| Sepsis | Blood | 12 | 5 (3), 1 (2), 23A (2), 23F (1), 3 (1), 14 (1), 10F/C/33C (1), 35B (1) | 9/12 (75%) | 10/12 (83.3%) | ||
| Subtotal | 84 | 56/84 (66.7%) | 58/84 (69%) | ||||
| 5–15 years | |||||||
| Meningitis | CSF | 4 | 7A/F (1), 11A/D (1), 24A//B/F (1), NT (1) | 0/4 (0%) | 0/4 (0%) | ||
| Sepsis | Blood | 3 | 18A/B/C/F (1), 1 (1), 19F (1) | 3/3 (100%) | 3/3 (100%) | ||
| Empyema | Pleural fluid | 2 | 19F (2) | 2/2 (100%) | 2/2 (100%) | ||
| Subtotal | 9 | 5/9 (55.6%) | 5/9 (55.6%) | ||||
| Adults (18–70 years) | |||||||
| Meningitis | CSF | 5 | 5 (1), 13 (1), 19F (1), 22A/F (1), NT (1) | 2/5 (40%) | 2/5 (40%) | ||
| Sepsis | Blood | 8 | 1 (2), 23F (2), 13 (1), 15B/C (1), 38/25F/25A (1) | 4/8 (50%) | 4/8 (50% | ||
| Other ** | See below | 5 | 19F (3), 1 (1), 14 (1) | 5/5 (100%) | 5/5 (100%) | ||
| Subtotal | 18 | 11/18 (61.1%) | 11/18 (61.1%) | ||||
| TOTAL | 111 | 72/111 (64.9%) | 74/111 (66.7%) |
*Includes Vaccine -related (VR) serotypes.
†
NT = Non-typeable.
**Ascitic fluid (n = 3), synovial fluid (n = 1), unknown sterile body fluid (n = 1).