Table 2.
Physical characteristics of mammary tumors from transgenic mice
| Characteristic | Incidence per tumor
|
|
|---|---|---|
| WAP-c-Myc | NRL-TGFαa | |
| Histotype | Solid adenocarcinoma 6/6 | Hypersecretory papillary cystic tumors 26/29 Solid adenocarcinoma 3/29 |
| Grade | III: 6/6* | I: 6/29 II: 23/29 |
| Necrosis | 5/6* | 0/29 |
| Stromal invasion | 4/6* | 0/29 |
| Vascular invasion | 3/6* | 0/29 |
| Lymph node metastasis | 0/6 | 0/29 |
| Lung metastasis | 11/14* | None grossly evident |
| Liver metastasis | 2/10* | None grossly evident |
a
29 tumors were evaluated in 26 NRL-TGFα mice
*
Statistically differences between WAP-c-Myc and NRL-TGFα mice.
Significance levels at P < 0.05 Fisher’s Exact Test