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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: Semin Cell Dev Biol. 2014 Mar 21;0:121–130. doi: 10.1016/j.semcdb.2014.03.017

Figure 3. Genetic interaction network of MCM10.

Figure 3

Summary of genes that show synthetic loss of fitness or synthetic increase in survival with mcm10. The lists of genes on the left and right were generated from published reports [32, 34, 35, 46, 47] and a synthetic genetic array (SGA) screen ([48]; Thu, Nguyen and Bielinsky, unpublished; except mms21 and ubc9 [79]). Red letters indicate essential genes; blue letters mark non-essential genes. Red panels represent negative genetic interactions; the blue panel shows positive genetic interactions. Underlined genes encode proteins that physically interact with Mcm10. The space-filling model at the center shows the internal domain of XMcm10 with a trace of ssDNA [6]. The image was generated by importing the protein data bank (pdb) file 3EBE into the Chimera program (http://www.cgl.ucsf.edu/chimera) [80].