Skip to main content
. 2014 Jun 3;9(6):e98658. doi: 10.1371/journal.pone.0098658

Figure 11. A possible scheme for the protective effects of CMZ against chronic ethanol-induced fatty liver.

Figure 11

Ethanol-induced CYP2E1 activation can lead to the suppression of PPAR-α, which may be related with the decline of the p300 protein level, the increase of PGC-1α acetylation, and the disturbance of several protein kinases including AMPK, MAPK, and GSK3β. CYP2E1 activation can also result in oxidative stress, which will lead to the overproduction of TNF-α by activating kupffer cells. In contrast, the protective effects of CMZ against AFL might not be associated with the SREBP-1 mediated lipogenesis and autophagy pathway, which are needed to be confirmed in future studies.