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. Author manuscript; available in PMC: 2015 Jun 15.
Published in final edited form as: Arch Biochem Biophys. 2014 Jan 31;0:117–127. doi: 10.1016/j.abb.2014.01.015

Figure 1. Model geometry and half-sarcomere organization.

Figure 1

A) The shaded parallelogram roughly outlines the cross-sectional view of modeled interactions between four thick-filaments (red) and eight regulated thin-filaments (actin=blue, troponin=green, tropomyosin=magenta) of half-sarcomere length. The expanded inset illustrates one potential myosin-actin cross-bridge interaction between two adjacent filaments. Axial, half-sarcomere illustrations show filament interactions for simulations of B) 1150 nm (=2.3 µm SL) and C) 1300 nm (=2.6 µm SL) for uniform (upper) and random (lower) reductions in myosin content at each SL. Titin is represented as the link between thick-filament backbones and the Z-line.