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. 2014 Jun 3;9(6):e98306. doi: 10.1371/journal.pone.0098306

Figure 5. Confocal fluorescence microscopy with false colour showing the localization of progerin (green) in nuclei (blue) in human myogenic cells.

Figure 5

In HGPS fibroblast cultures, progerin positive nuclei are mostly lobulated or trabeculated (A–C). Human myogenic cells transfected with PMOs also demonstrated abnormally shaped progerin reactive nuclei (D–F: transfected with 1 µM PMO 421; G–I: 0.5 µM PMO 422). Untreated cells did not contain any detectable progerin positive nuclei (J–L). Magnification: 60×. Scale bar: 50 µm.