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. 2014 Jun 3;9(6):e98809. doi: 10.1371/journal.pone.0098809

Figure 1. Genotype of the ATP7B KO cell line after ZFN directed mutagenesis.

Figure 1

Top line shows the schematic structure of the entire WD gene (exons boxed). Middle lines represent a blow-up of exon 8 and specify the sequence of the proposed ZFN binding sites (boxed) and the FOKI restriction site (arrow). The four bottom lines specify the nucleotide sequences and codons of wild type (upper two lines) and the nucleotide sequence of both chromosomes observed in KO cell (last two lines). Dashes indicate the observed deletions.