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. 2014 Jun 4;34(23):7988–7998. doi: 10.1523/JNEUROSCI.0777-14.2014

Figure 7.

Figure 7.

Decreasing mTOR signaling increases autophagy induction. A, Representative Western blots of protein extracted from 12-month-old APP and APP/mTOR+/− mice. Blots were probed with the indicated antibodies. B–E, Quantification of the blots shows that the levels of Atg3, Atg5, Atg7 and Atg12 were significantly higher in the APP/mTOR+/− than APP mice (n = 5/genotype). F, Representative microphotographs of hippocampal sections immunostained with the indicated antibodies. G, Semiquantitative analysis showed that the number of yellow pixels (indicating a colocalization between Aβ and the lysosomal protein Lamp2A) was significantly higher in APP/mTOR± mice compared with APP mice (n = 7/genotype). Data are presented as means ± SEM and were analyzed by t test; *p < 0.01, **p < 0.001.