Fig. 2.

Model of adipocytes as antigen presenting cells. Adipocytes could act as antigen presenting cells via expression of key molecules for antigen presentation in obese adipose tissue. Adipocytes expressing MHC I could mediate CD8 T cell responses whereas those expressing MHC II molecules could regulate CD4 T cell responses. In addition, adipocytes could modulate the function and activation of iNKT cells via high expression of CD1d molecules in adipose tissue.