Table 1.
Subject demographics
| Demographics | Women (n = 22) | Men (n = 3) |
|---|---|---|
| Age, yr | 41.2 ± 11.7 (33.9–51) | 43.1 ± 3.7 (38.9–45.7) |
| Anthropometrics | ||
| BMI, kg/m2 | 45.9 ± 3.0 (44.0–48.4) | 46.1 ± 2.6 (44.2–49.1) |
| Neck, cm | 39.4 ± 2.8 (38.0–40.7) | 46.4 ± 1.8 (44.5–48.1) |
| Waist, cm | 128.6 ± 24.2 (118.4–133.3) | 139.4 ± 11.1 (126.8–147.7) |
| Waist-to hip ratio | 0.9 ± 0.1 (0.9–0.9) | 1.0 ± 0.0 (1.0–1.0) |
| Girth, cm | 34.0 ± 20.1 (28.0–32.0) | 33.3 ± 4.0 (29.0–37.0) |
| Sleep architecture | ||
| TST, min | 394.4 ± 65.5 (367.5–442.4) | 425.3 ± 100.0 (358.0–540.0) |
| Sleep efficiency, % | 85.2 ± 12.7 (82.0–93.0) | 94.8 ± 2.4 (92.0–96.5) |
| Stage N1, %TST | 15.0 ± 11.0 (9.5–16.7) | 21.6 ± 13.8 (5.7–30.6) |
| Stage N2, %TST | 56.8 ± 7.6 (51.1–62.0) | 55.1 ± 10.0 (46.1–65.8) |
| Stage N3, %TST | 11.5 ± 10.3 (1.3–19.2) | 3.3 ± 5.7 (0.0–9.8) |
| REM, %TST | 16.7 ± 8.3 (11.2–23.7) | 20.0 ± 4.9 (15.9–25.4) |
| Sleep-Disordered Breathing | ||
| Non-REM | ||
| AHI events/h | 22 ± 28 (5–23) | 65.4 ± 39.4 (30.7–108.2) |
| Baseline SaO2 | 96.0 ± 1.9 (94.7–97.5) | 95.1 ± 0.9 (94.3–96.0) |
| Average low SaO2 | 91.7 ± 2.4 (89.4–93.6) | 87.4 ± 3.9 (83.4–91.1) |
| REM | ||
| AHI events/h | 32 ± 23 (10–47)* | 80 ± 12 (68–92) |
| Baseline SaO2 | 95.7 ± 1.9 (95.0–97.4)* | 93.8 ± 1.8 (91.8–95.2) |
| Average low SaO2 | 90.0 ± 2.9 (88.6–91.4)* | 82.5 ± 5.3 (79.4–88.6) |
| Total | ||
| AHI events/h | 24.8 ± 26.2 (6.4–31.6) | 69 ± 33 (43–106) |
| Baseline SaO2 | 95.9 ± 1.9 (95.0–97.3) | 94.7 ± 0.8 (94.3–95.6) |
| Average low SaO2 | 90.9 ± 2.2 (89.7–92.8) | 86.2 ± 3.5 (83.0–89.9) |
| Arterial Blood Gases (19 woment/2 men) | ||
| PaO2 | 86.6 ± 13.2 (77.5–94.5) | 73.5 ± 4.95 (70.0–77.0) |
| PaCO2 | 38.9 ± 5.12 (37.0–42.5) | 45.5 ± 4.95 (42.0–49.0) |
| pH | 7.42 ± 0.04 (7.40–7.44) | 7.40 ± 0.02 (7.38–7.41) |
| Pulmonary Function Tests (21 women, 3 men) | ||
| FVC, liters | 3.42 ± 0.71 (2.88–3.92) | 5.09 ± 0.12 (5.05–5.16) |
| FVC predicted, % | 96.4 ± 16.4 (88.0–112.9) | 104 ± 3.90 (102.9–106.3) |
| FEV1, liters | 2.77 ± 0.55 (2.40–3.09) | 3.90 ± 0.04 (3.89–3.93) |
| FEV1 predicted, % | 93.5 ± 14.6 (82.0–101.8) | 96.2 ± 1.72 (95.3–97.0) |
| FEV1/FVC, % | 81.4 ± 4.70 (77.8–84.6) | 86.6 ± 13.2 (75.4–77.8) |
| Serum Leptin, ng/ml | 95.2 ± 32.6 (74.2–114.2) | 43.4 ± 10.3 (31.6–50.2) |
| Passive PCRIT, cmH2O | 0.2 ± 3.3 (−2.5–1.7) | −1.1 ± 2.2 (−3.2–1.2) |
| Active PCRIT, cmH2O | −2.9 ± 0.9 (−5.5–−0.7) | −1.9 ± 1.1 (−3.1–−3.1) |
All values are presented as mean ± SD (25–75th percentile).
AHI, apnea-hypopnea index; BMI, body mass index; SaO2, oxygen saturation; TST, total sleep time.
*
Three women had no rapid eye movement (REM) sleep.