Fig. 4.

Intrathecal preapplication of prazosin (1 mM; n = 9) did not affect the hypoxia responses (A) (t-test) nor the magnitude of AIH-induced pLTF (B) compared with intrathecal vehicle preapplication (20% DMSO) + AIH (n = 7). Thus α₁ receptor activation is not necessary for AIH-induced pLTF (***P < 0.001, **P < 0.01 significantly different from baseline; ^###P < 0.001, ^##P < 0.01, #P < 0.05 significantly different from 30 min; ^@@@P < 0.001, ^@@P < 0.01 significantly different from 15 min; two-way repeated measures ANOVA, Fishers LSD post hoc test). In (B), significance symbols relative to vehicle data appear below data lines; significance symbols relative to prazosin appear above data lines.