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. 2014 Mar 26;111(12):2493–2504. doi: 10.1152/jn.00764.2013

Fig. 3.

Fig. 3.

5-HT1AR activation decreases afferent synaptic transmission and excitatory nTS network activity. A: representative example (average of 20 sweeps) of the reduction in TS-excitatory postsynaptic current (EPSC) amplitude induced by the 5-HT1AR agonist 8-OH-DPAT (10 μM). B: individual data for the response to 8-OH-DPAT displayed as raw values (left) and normalized to baseline (right, baseline defined as “1”). The summary bars show the geometric mean with 95% confidence interval (CI). n = 10. *P < 0.05. C: representative example of the reduction in spontaneous EPSC (sEPSC) event frequency induced by 8-OH-DPAT. D: cumulative fraction of sEPSC intervals shows a significant shift (n = 11; P < 0.05, Kolmogorov-Smirnov two-sample test) to longer intervals in the presence of 8-OH-DPAT. E: individual data for the sEPSC frequency response to 8-OH-DPAT displayed as raw values (left) and normalized to baseline (right, baseline defined as “1”). Bars show geometric mean with 95% CI; n = 11. ***P < 0.001.