Table 3.
Altered inhibitory postsynaptic receptor function with 5-HT1AR activation
| TTX + NBQX + AP5 | 8-OH-DPAT + TTX + NBQX + AP5 | n | P Value | |
|---|---|---|---|---|
| mIPSC frequency, Hz | 0.9 (0.5–1.6) | 0.9 (0.4–1.9) | 8 | 0.95 |
| mIPSC amplitude, pA | 33.1 (25–45) | 29.3 (21–41) | 8 | <0.05 |
| mIPSC rise time, ms | 3.2 (2.9–3.7) | 3.6 (3.2–4.1) | 8 | 0.17 |
| mIPSC decay time, ms | 4.8 (4.6–5.0) | 4.6 (4.2–5.1) | 8 | 0.84 |
Values are geometric means (with lower and upper 95% confidence intervals in parentheses). Group values depict indicators for changes occurring pre- or postsynaptically. Note, activation of 5-HT1ARs significantly decreased miniature inhibitory postsynaptic current (mIPSC) amplitude, implying a change at the postsynaptic receptor. TTX, tetrodotoxin; NBQX, 1,2,3,4-tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulfonamide disodium; AP5, dl-2-amino-5-phosphonovaleric acid.