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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: J Pediatr Surg. 2014 Jan 31;49(6):938–944. doi: 10.1016/j.jpedsurg.2014.01.030

Figure 2. MSC intestinal engraftment.

Figure 2

(A) Shown are representative fluorescent microscopy images of: a) uninjured jejunum from an animal subjected to sMAO and treated with scrambled control-transfected BM-MSC, b) terminal ileum from an animal treated subjected to sMAO and treated with scrambled control-transfected BM-MSC, c) terminal ileum from an animal subjected to sMAO and treated with HB-EGF-transfected BM-MSC, d) uninjured jejunum from an animal subjected to sMAO and treated with scrambled control-transfected AF-MSC, e) terminal ileum from an animal treated subjected to sMAO and treated with scrambled control-transfected AF-MSC, and f) terminal ileum from an animal subjected to sMAO and treated with HB-EGF-transfected AF-MSC. (B) Quantification of BM-MSC intestinal engraftment. Mice were subjected to sMAO or to sham surgery. There was increased BM-MSC engraftment into sMAO injured ileum compared to sMAO uninjured jejunum or sham uninjured ileum. Values represent mean ± SD with ≥ 5 animals per group. *p< 0.01 compared to sMAO uninjured jejunum or to sham operated ileum. (C) Quantification of AF-MSC intestinal engraftment. Mice were subjected to sMAO or to sham surgery. There was increased AF-MSC engraftment into sMAO injured ileum compared to sMAO uninjured jejunum or sham uninjured ileum. In addition, there was increased engraftment of HB-EGF-transfected AF-MSC compared to scrambled control-transfected AF-MSC into sMAO inured ileum. Values represent mean ± SD with ≥ 5 animals per group. *p< 0.01 compared to sMAO uninjured jejunum or to sham operated ileum; **p< 0.01 compared to sMAO uninjured jejunum or to sham operated ileum, and p<0.05 compared to sMAO injured ileum treated with scrambled control-transfected AF-MSC.