Table 2. Heat capacity changes and change in the solvent-accessible surface area for the duck Na,K-ATPase binding to AMP, ADP and ATPa.
Ligand | ΔCp, cal·mole−1·K−1 | ΔAtot_minb, Å2 | ΔAtot_maxb, Å2 |
---|---|---|---|
AMP | −66 | 349 | 551 |
ADP | −43 | 228 | 333 |
ATP | −760 | 4021 | 5891 |
aHeat capacity changes were obtained as d(ΔH)/dT from Figure 2.
bChanges in solvent-accessible surface area were estimated using the following formula: ΔCp = k × ΔAtot, where ΔAtot is the total change in solvent accessible surface area in Å2. ΔAtot_max and ΔAtot_min are calculated for the min and max k values (0.129 and 0.189 cal/(K·mol·Å2), as shown in21).