Skip to main content
. 2014 Jun;184(6):1831–1842. doi: 10.1016/j.ajpath.2014.03.003

Figure 7.

Figure 7

ERK pathway activation in VEH- and ActRIIB-treated mice. A: Western blot analysis shows the relative expression of total ERK, p-ERK, total RSK/P90, and p-RSK/P90 in the quadriceps and gastrocnemius muscles of (VEH- and ActRIIB-treated WT and R69C mice at 6 MOL. GAPDH staining is used as a basis for loading and quantification studies. The numbers under each set of two lanes refer to individual mice from the study. B: Quantification of the Western blot results shown in A. Expression is normalized to the GAPDH expression for each lane. These values were obtained from gels in which the WT and R69C samples were run in parallel on the same gels and immunoblotted on the same membranes. Data are expressed as means ± SEM. ∗P < 0.05. ActRIIB, ActRIIB-mFC; G, gastrocnemius; Q, quadriceps; R69C, Mtm1 p.R69C; VEH, vehicle.