Mice with RB-sufficient and RB-deficient livers were treated with TCPOBOP, Wy-14,643, and MCDD. A: Effects on gene expression as determined by real-time PCR analysis. B: Excised livers were weighed and normalized to body weight. For each condition, at least five livers were measured. C: Representative images of liver tissue from mice treated with TCPOBOP, Wy-14,643, and MCDD stained with H&E. Data are presented as means ± SD (A and B). ∗P < 0.05 versus untreated as determined by Welch's t-test. Original magnification: ×20. UNT, untreated.