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. 2014 Jun;184(6):1819–1830. doi: 10.1016/j.ajpath.2014.02.012

Figure 5.

Figure 5

Pik3c3-cKO mice exhibit dystrophic muscle by independent measures. A: CPK measurements of serum obtained from the distal saphenous vein show increases of nearly 50-fold in excess when KO (mean = 5452 ± 1263 mU/mL) are compared to WT littermates (mean = 233.3 ± 65.51 mU/mL). B: EBD is taken up by dystrophic fibers after 24 hours of incubation following peritoneal injection. EBD is shown in red and counterstained against the extracellular membrane protein Laminin in green. Data are expressed as means ± SEM. n = 4 KO and 4 WT mice. ∗∗∗P < 0.001.