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. Author manuscript; available in PMC: 2014 Jun 4.
Published in final edited form as: Nat Neurosci. 2013 Dec 22;17(2):304–311. doi: 10.1038/nn.3606

Figure 1.

Figure 1

Whole-brain ROI analysis identified dysfunction in the entorhinal cortex and other cortical regions in preclinical Alzheimer’s disease. (a) An example of automated whole-brain segmentation of a CBV image. Left, pre-contrast image in a coronal view (for illustration purposes the right brain is shown unsegmented). Right, sagittal view. (b) Compared with a control group (light gray bars), the preclinical group (dark gray bars) showed reliable reductions in the percentage of CBV in the entorhinal cortex and parahippocampal gyrus. *P < 0.05. Error bars represent s.e.m. (c) Among brain regions affected in preclinical Alzheimer’s disease, only the parahippocampal gyrus and the precuneus cortex were significantly correlated with entorhinal cortex dysfunction by a correlational analysis (**Pearson correlation coefficient >0.7).