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. Author manuscript; available in PMC: 2014 Jun 4.
Published in final edited form as: Nat Neurosci. 2013 Dec 22;17(2):304–311. doi: 10.1038/nn.3606

Figure 2.

Figure 2

Voxel-based analysis pinpoints dysfunction in preclinical Alzheimer’s disease to the LEC. (a) A voxel-based analysis was performed in the temporal lobes (indicated by highlighted areas at left) and the voxels that showed significantly lower CBV in the preclinical are indicated in color in a coronal view (left) and an axial view (right). (b) A higher magnification of the coronal view showing the anatomy of the medial temporal (left and middle). Right, LEC and PRC were the regions with reliable CBV reductions in the preclinical compared to the control group. TEC, transentorhinal cortex; HC, hippocampus proper. (c) An analysis of the control group pinpointed the right LEC as a region in which CBV was correlated with performance on a delayed retention task. Statistics are represented as heat maps of t values corresponding to P < 0.05, corrected for multiple comparisons using the FWE approach.