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. Author manuscript; available in PMC: 2014 Jun 4.
Published in final edited form as: Nat Neurosci. 2013 Dec 22;17(2):304–311. doi: 10.1038/nn.3606

Figure 3.

Figure 3

The LEC is affected by tau and APP coexpression and leads to cortical dysfunction. (a) A volume rendering of the mouse brain, mapping the anatomical locations of the LEC (yellow), MEC (white) and PRC (red). (b) Voxel-based analyses revealed that, compared with controls, EC-APP mice had CBV reductions in the MEC and the CA1 (left), EC-Tau mice showed little differences in CBV (middle), and EC-APP/Tau mice had reliable CBV reductions [in the left LEC and PRC (right). All images are axial slices whose location is illustrated in the volume rendering shown in a. (c) A higher magnification of the slice (as illustrated in the stippled box in the right panel of b) shows the anatomy of the medial temporal region (left and middle; SUB, subiculum; DG, dentate gyrus), and shows that the LEC and the PRC were the regions with reliable CBV reductions in the EC-APP/Tau group (right). (d) More dorsal slices of the EC-APP/Tau group showing additional areas of reduced CBV in the PRC (left and middle) and reduced CBV in PPC (right).