Figure 4.

Patterns of cortical spread in mouse models overlap with patterns observed in preclinical Alzheimer’s disease. (a) As illustrated by volume rendering, the brain regions affected in the EC-APP/Tau mice are the LEC (yellow), PRC (red) and the PPC (green). (b) As illustrated by volume rendering, among the regions affected in the human preclinical group, dysfunction in the entorhinal cortex (yellow) was reliably correlated with CBV in the parahippocampal gyrus (red) and precuneus (green).