Skip to main content
. Author manuscript; available in PMC: 2014 Jun 4.
Published in final edited form as: Nat Neurosci. 2013 Dec 22;17(2):304–311. doi: 10.1038/nn.3606

Figure 6.

Figure 6

Mapping histological markers of tau and APP in mouse models. (a) Histology analysis in the MTL of APP/Aβ with 6E10 antibody in young EC-APP and EC-APP/Tau mice (left), abnormally conformed human tau with MC1 antibody in young EC-Tau and EC-APP/Tau mice (middle), and total human tau with CP27 antibody in young EC-Tau and EC-APP/Tau (right). Scale bar represents 500 µm.

(b) Histology analysis in the MTL of APP/Aβ with 6E10 antibody in old EC-APP and EC-APP/Tau mice (left), conformation changes in tau with MC1 antibody in old EC-Tau and EC-APP/Tau mice (middle), and total human tau with CP27 antibody in old EC-Tau and ECAPP/Tau mice (right). Scale bar represents 500 µm. (c) Histology analysis in the MTL of phospho-tau with AT8 antibody in old EC-Tau and EC-APP/Tau mice (left). In older EC-APP/Tau mice, MC1 immunohistochemistry (20×) revealed the occurrence of redistribution of tau from axons into the somatodendritic compartments compared with EC-Tau mice (middle). A semiquantitative analysis revealed a significant increase in MC1-positive neurons in the entorhinal cortex in the EC-APP/Tau mice (440.1 ± 79.60, n = 7), mainly in the MEC, compared with the EC-Tau mice (99.80 ± 22.92, n = 5; t-test, P = 0.006; right). Data are presented as mean ± s.e.m. Scale bars represent 500 µm (left) and 100 µm (middle). (d) Histology analysis in the parietal lobe of APP/Aβ with 6E10 antibody in old EC-APP and EC-APP/Tau mice (left), conformation changes in tau with MC1 antibody in old EC-Tau and EC-APP/Tau mice (middle), and phospho-tau with AT8 antibody in old EC-Tau and EC-APP/Tau mice (right). Scale bar represents 500 µm.