Table 3.
Relative risk of mortality by all causes by the serum aminotransferase concentration at baseline (expressed as floating absolute risks)
|
All causes
|
Cancers
|
Cardiovascular diseases
|
Diseases of digestive system
|
||||||
|---|---|---|---|---|---|---|---|---|---|
| Total No of Participants | No of deaths | RR*(95% CI) | No of deaths | RR*(95% CI) | No of deaths | RR*(95% CI) | No of deaths | RR*(95% CI) | |
| Men | |||||||||
| AST (IU/I): | |||||||||
| <20 | 26 416 | 619 | 1.0 (0.9 to 1.1) | 292 | 1.0 (0.9 to 1.1) | 118 | 1.0 (0.8 to 1.2) | 18 | 1.0 (0.6 to 1.6) |
| 20-29 | 48 185 | 1 494 | 1.3 (1.2 to 1.4) | 665 | 1.2 (1.1 to 1.3) | 318 | 1.4 (1.2 to 1.5) | 58 | 1.8 (1.4 to 2.4) |
| 30-39 | 13 964 | 590 | 1.7 (1.6 to 1.9) | 262 | 1.7 (1.5 to 1.9) | 107 | 1.4 (1.2 to 1.7) | 51 | 5.6 (4.2 to 7.3) |
| 40-49 | 3 127 | 219 | 2.7 (2.4 to 3.1) | 98 | 2.8 (2.3 to 3.4) | 33 | 1.8 (1.3 to 2.5) | 36 | 16.9 (12.2 to 23.5) |
| 50-99 | 2 397 | 358 | 5.4 (4.9 to 6.0) | 158 | 5.5 (4.7 to 6.4) | 39 | 2.6 (1.9 to 3.6) | 79 | 42.7 (34.1 to 53.6) |
| ≥100 | 444 | 112 | 8.6 (7.2 to 10.4) | 39 | 6.7 (4.9 to 9.2) | 9 | 3.3 (1.7 to 6.4) | 46 | 120.4 (89.2 to 162.5) |
| ALT (IU/I): | |||||||||
| <20 | 37 425 | 1 061 | 1.0 (0.9 to 1.1) | 494 | 1.0 (0.9 to 1.1) | 197 | 1.0 (0.9 to 1.2) | 34 | 1.0 (0.7 to 1.4) |
| 20-39 | 36 589 | 1 197 | 1.2 (1.1 to 1.3) | 535 | 1.2 (1.1 to 1.3) | 263 | 1.3 (1.2 to 1.5) | 61 | 2.1 (1.6 to 2.7) |
| 30-39 | 11 975 | 516 | 1.7 (1.5 to 1.8) | 215 | 1.6 (1.4 to 1.8) | 85 | 1.3 (1.0 to 1.6) | 60 | 6.9 (5.4 to 9.0) |
| 40-49 | 4 068 | 225 | 2.2 (1.9 to 2.5) | 93 | 2.1 (1.7 to 2.6) | 38 | 1.7 (1.2 to 2.3) | 40 | 13.5 (9.9 to 18.5) |
| 50-99 | 3 887 | 310 | 3.0 (2.7 to 3.4) | 133 | 3.1 (2.6 to 3.6) | 32 | 1.4 (1.0 to 2.0) | 72 | 23.4 (18.5 to 29.6) |
| ≥100 | 589 | 83 | 5.2 (4.2 to 6.4) | 44 | 6.2 (4.6 to 8.3) | 9 | 2.9 (1.5 to 5.6) | 21 | 41.0 (26.7 to 63.1) |
| Women | |||||||||
| AST (IU/I): | |||||||||
| <20 | 25 362 | 185 | 1.0 (0.9 to 1.2) | 104 | 1.0 (0.8 to 1.2) | 28 | 1.0 (0.7 to 1.6) | 1 | 1.0 (0.1 to 7.1) |
| 20-29 | 19 463 | 174 | 1.0 (0.9 to 1.2) | 113 | 1.2 (1.0 to 1.5) | 22 | 0.7 (0.5 to 1.1) | 2 | 2.3 (0.3 to 16.7) |
| 30-39 | 2 114 | 24 | 1.2 (0.7 to 1.6) | 12 | 1.0 (0.6 to 1.8) | 2 | 0.4 (0.1 to 1.6) | 2 | 18.5 (2.8 to 139.6) |
| 40-49 | 336 | 3 | 0.8 (0.3 to 2.5) | 3 | 1.5 (0.5 to 4.6) | 0 | — | 0 | — |
| ≥50 | 247 | 8 | 2.9 (1.4 to 5.8) | 3 | 2.1 (0.7 to 6.5) | 0 | — | 3 | — |
| ALT (IU/I): | |||||||||
| <20 | 35 187 | 257 | 1.0 (0.9 to 1.2) | 154 | 1.0 (0.8 to 1.2) | 32 | 1.0 (0.6 to 1.6) | 2 | 1.0 (0.3 to 4.0) |
| 20-29 | 10 201 | 103 | 1.2 (1.0 to 1.4) | 62 | 1.2 (0.9 to 1.5) | 17 | 1.3 (0.8 to 2.2) | 2 | 2.7 (0.7 to 11.8) |
| 30-39 | 1 380 | 19 | 1.4 (0.9 to 2.2) | 11 | 1.4 (0.8 to 2.6) | 3 | 1.3 (0.4 to 4.1) | 0 | — |
| 40-49 | 365 | 10 | 3.0 (1.6 to 5.6) | 6 | 3.1 (1.4 to 6.8) | 0 | — | 2 | 75.0 (19.7 to 314.7) |
| ≥50 | 389 | 5 | 1.2 (0.5 to 3.0) | 2 | 0.9 (0.2 to 3.5) | 0 | — | 2 | 80.8 (19.7 to 314.4) |
AST=aspartate aminotransferase, ALT=alanine aminotransferase.
*
Adjusted for age, body mass index, smoking status, alcohol consumption, plasma glucose, serum total cholesterol, blood pressure, and family history of liver disease.