Table 4.
Relative risk of mortality from liver diseases in men by serum aminotransferase concentration at baseline (expressed as floating absolute risks)
|
Total No of participants
|
Liver diseases
|
Liver cancer
|
Non-cancer liver diseases
|
||||
|---|---|---|---|---|---|---|---|
| No of deaths | RR*(95% CI) | No of deaths | RR*(95% CI) | No of deaths | RR*(95% CI) | ||
| AST (IU/I): | |||||||
| <20 | 26 416 | 25 | 1.0 (0.7 to 1.5) | 14 | 1.0 (0.6 to 1.7) | 11 | 1.0 (0.6 to 1.8) |
| 20-29 | 48 185 | 108 | 2.5 (2.0 to 3.0) | 76 | 3.1 (2.5 to 3.9) | 32 | 1.7 (1.2 to 2.3) |
| 30-39 | 13 964 | 98 | 8.0 (6.6 to 9.8) | 64 | 9.4 (7.4 to 12.0) | 34 | 6.2 (4.4 to 8.7) |
| 40-49 | 3 127 | 70 | 25.7 (20.3 to 32.5) | 44 | 29.5 (21.9 to 39.8) | 26 | 20.8 (14.1 to 30.6) |
| 50-99 | 2 397 | 149 | 65.7 (55.8 to 77.4) | 92 | 74.6 (60.7 to 91.8) | 57 | 55.0 (42.2 to 71.7) |
| ≥100 | 444 | 51 | 111.3 (84.0 to 147.4) | 17 | 65.4 (30.4 to 105.9) | 34 | 167.2 (117.8 to 237.2) |
| ALT (IU/I): | |||||||
| <20 | 37 425 | 45 | 1.0 (0.7 to 1.4) | 27 | 1.0 (0.7 to 1.5) | 18 | 1.0 (0.6 to 1.6) |
| 20-29 | 36 589 | 113 | 2.9 (2.4 to 3.5) | 82 | 3.4 (2.8 to 4.3) | 31 | 2.0 (1.4 to 2.8) |
| 30-39 | 11 975 | 110 | 9.5 (7.9 to 11.5) | 64 | 9.3 (7.3 to 11.9) | 46 | 9.9 (7.4 to 13.2) |
| 40-49 | 4 068 | 74 | 19.2 (15.3 to 24.2) | 44 | 19.3 (14.3 to 26.0) | 30 | 19.1 (13.3 to 27.4) |
| 50-99 | 3 887 | 117 | 30.0 (25.0 to 36.1) | 69 | 30.2 (23.8 to 38.4) | 48 | 29.6 (22.2 to 39.5) |
| ≥100 | 589 | 42 | 59.0 (43.4 to 80.1) | 21 | 46.8 (30.4 to 72.1) | 21 | 78.5 (51.0 to 120.9) |
AST=aspartate aminotransferase, ALT=alanine aminotransferase.
*
Adjusted for age, body mass index, smoking status, alcohol consumption, plasma glucose, serum total cholesterol, blood pressure, and family history of liver disease.