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. 2014 May 28;8:627–637. doi: 10.2147/DDDT.S63088

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© 2014 Bahi et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Effects of acute ST-1283 pretreatment on anxiety-like behavior in the open field test and marbles burying test. In the open field test, ST-1283 had no effect on total line crossing (A) but dose-dependently increased the time spent in the center of the arena (B). In the marbles burying test, acute ST-1283 decreased the number of buried marbles (C) and the time spent digging (D).

Notes: *Denotes significant differences between drug doses and saline controls (P<0.05); ^#denotes significant differences between diazepam and saline controls (P<0.001). Vehicle n=9; ST-1283 5 mg/kg n=10; ST-1283 7.5 mg/kg n=7, DZP n=8. Data are shown as the mean ± standard error of the mean.

Abbreviation: DZP, diazepam.