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. 2014 May 28;8:627–637. doi: 10.2147/DDDT.S63088

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© 2014 Bahi et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Effects of acute RAMH pretreatment on ST-1283-induced anxiolytic effects in the open field test and marbles burying test. In the open field test, RAMH pretreatment had no effect on total line crossing (A) but abrogated the effects of ST-1283 on the time spent in the center of the arena (B). In the marbles burying test, acute RAMH pretreatment blocked the effects of ST-1283 on the number of buried marbles (C) and time spent digging (D).

Notes: *Denotes significant differences between ST-1283 and saline controls (P<0.05); ^#denotes significant differences between RAMH and ST-1283 (P<0.05). Vehicle n=7; ST-1283 7.5 mg/kg n=6, RAMH n=8. Data are shown as the mean ± standard error of the mean.

Abbreviation: RAMH, R-α-methylhistamine.