Table 3.
Breast cancer-specific mortality, by tumor subtype, in Hispanic Women in California, 2005–2010
| All subtypes
|
HR+/HER2−
|
Triple negative
|
HR+/HER2+
|
HR−/HER2+
|
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Deaths (n=993) |
HR (95% CI) | Deaths (n=345) |
HR (95% CI) | Deaths (n=357) |
HR (95% CI) | Deaths (n=133) |
HR (95% CI) | Deaths (n=158) |
HR (95% CI) | |
| Nativity | ||||||||||
| US-Born | 426 | Ref. | 138 | Ref. | 153 | Ref. | 66 | Ref. | 69 | Ref. |
| Foreign-Born | 567 | 0.97 (0.83–1.13) | 207 | 1.12 (0.86–1.47) | 204 | 0.99 (0.76–1.28) | 67 | 0.68 (0.43–1.06) | 89 | 0.72 (0.48–1.08) |
| Socioeconomic status | ||||||||||
| Quintile 1 (Low) | 336 | 1.76 (1.25–2.49) | 117 | 1.62 (0.91–2.88) | 120 | 1.21 (0.69–2.13) | 41 | 2.85 (0.90–9.00) | 58 | 4.02 (1.35–11.99) |
| Quintile 2 | 230 | 1.67 (1.19–2.36) | 77 | 1.32 (0.74–2.34) | 76 | 1.14 (0.65–1.98) | 31 | 2.84 (0.91–8.86) | 46 | 4.95 (1.70–14.40) |
| Quintile 3 | 179 | 1.54 (1.10–2.15) | 58 | 1.31 (0.74–2.32) | 79 | 1.44 (0.85–2.44) | 22 | 2.34 (0.79–6.93) | 20 | 1.79 (0.59–5.38) |
| Quintile 4 | 127 | 1.38 (0.98–1.94) | 43 | 1.04 (0.59–1.83) | 40 | 1.02 (0.59–1.79) | 23 | 2.46 (0.83–7.30) | 21 | 3.01 (1.03–8.77) |
| Quintile 5 (High) | 69 | Ref.† | 29 | Ref. | 23 | Ref. | 8 | Ref. | 9 | Ref.† |
| Hispanic enclave | ||||||||||
| Quintile 1 (Low) | 63 | Ref. | 19 | Ref. | 25 | Ref. | 9 | Ref. | 10 | Ref. |
| Quintile 2 | 117 | 1.05 (0.75–1.48) | 37 | 0.79 (0.43–1.46) | 47 | 1.25 (0.73–2.13) | 15 | 0.68 (0.24–1.90) | 18 | 1.65 (0.65–4.20) |
| Quintile 3 | 161 | 0.98 (0.71–1.36) | 56 | 1.01 (0.57–1.80) | 58 | 1.05 (0.62–1.80) | 24 | 0.70 (0.27–1.78) | 23 | 1.11 (0.44–2.83) |
| Quintile 4 | 238 | 0.92 (0.66–1.27) | 88 | 1.01 (0.57–1.80) | 84 | 0.98 (0.58–1.66) | 32 | 0.83 (0.33–2.09) | 34 | 0.84 (0.33–2.14) |
| Quintile 5 (High) | 382 | 0.92 (0.66–1.28) | 133 | 0.98 (0.55–1.77) | 128 | 1.11 (0.65–1.89) | 51 | 0.59 (0.22–1.60) | 70 | 0.94 (0.37–2.40) |
| Age at diagnosis (years0 | ||||||||||
| <45 | 245 | 0.94 (0.73–1.20) | 60 | 0.65 (0.42–1.03) | 116 | 1.35 (0.88–2.08) | 29 | 0.49 (0.25–0.96) | 40 | 1.37 (0.76–2.46) |
| 45–49 | 130 | 0.96 (0.73–1.27) | 48 | 0.79 (0.49–1.27) | 53 | 1.25 (0.77–2.03) | 12 | 0.55 (0.25–1.20) | 17 | 1.33 (0.66–2.67) |
| 50–54 | 149 | Ref. | 51 | Ref. | 43 | Ref. | 28 | Ref. | 27 | Ref. |
| 55–59 | 105 | 0.94 (0.70–1.26) | 40 | 0.98 (0.59–1.60) | 36 | 1.16 (0.69–1.95) | 9 | 0.33 (0.13–0.82) | 20 | 1.02 (0.50–2.07) |
| 60–64 | 81 | 0.90 (0.65–1.24) | 28 | 0.72 (0.42–1.26) | 30 | 1.45 (0.83–2.54) | 13 | 0.71 (0.29–1.70) | 10 | 0.90 (0.40–2.07) |
| ≥65 | 283 | 1.30 (1.01–1.67) | 118 | 1.09 (0.71–1.69) | 79 | 1.55 (0.95–2.52) | 42 | 1.01 (0.54–1.90) | 44 | 1.55 (0.84–2.86) |
| Marital status at diagnosis | ||||||||||
| Married | 507 | Ref. | 155 | Ref. | 204 | Ref. | 68 | Ref. | 80 | Ref. |
| Never married | 192 | 1.06 (0.87–1.29) | 72 | 1.40 (1.00–1.96) | 64 | 0.94 (0.67–1.32) | 24 | 0.89 (0.50–1.58) | 32 | 1.16 (0.70–1.93) |
| Prev. married | 248 | 1.14 (0.95–1.37) | 93 | 1.44 (1.05–1.98) | 79 | 0.86 (0.63–1.19) | 38 | 1.16 (0.71–1.89) | 38 | 1.42 (0.86–2.34) |
| Insurance status | ||||||||||
| Private | 394 | Ref. | 139 | Ref. | 146 | Ref. | 46 | Ref. | 63 | Ref. |
| Public | 500 | 1.13 (0.96–1.34) | 170 | 0.99 (0.74–1.33) | 180 | 1.23 (0.92–1.64) | 75 | 1.25 (0.77–2.01) | 75 | 1.12 (0.73–1.70) |
| Uninsured | 24 | 1.41 (0.88–2.26) | 9 | 1.58 (0.72–3.45) | 7 | 1.53 (0.68–3.43) | <5 | 3.11 (0.91–10.65) | 5 | 0.57 (0.14–2.35) |
| Subtype | ||||||||||
| HR+/HER2− | 345 | Ref. | ||||||||
| Triple Negative | 357 | 4.05 (3.35–4.90) | ||||||||
| HR+/HER2+ | 133 | 1.20 (0.95–1.52) | ||||||||
| HR−/HER2+ | 158 | 2.26 (1.80–2.84) | ||||||||
Notes. Cox models were adjusted for all variables presented in addition to year of diagnosis, tumor size (continuous), lymph node (yes/no), and first course of treatment (surgery, chemotherapy, and radiation therapy); AJCC stage levels I–IV and unknown was included as a stratifying variable. Abbreviations: Ref.=Referent category; HR=hazard ratio; CI=confidence interval. Bold text signifies statistically significant associations.
Public insurance included Medicaid and other government-assisted programs; and private insurance included health maintenance organizations, preferred provider organizations, managed care not otherwise specified, and military care.
p for trend <0.05.