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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: Am J Transplant. 2013 Dec 4;14(1):49–58. doi: 10.1111/ajt.12525

Figure 4. “Missing-self” does not induce rejection of MHC class I-deficient, syngeneic BMCs by recipient CD8 T cells.

Figure 4

CD45.1 C57BL/6 mice were conditioned with 3 Gy TBI on Day −1 and received NK and CD4 depleting mAbs on Days −1 and 7. After the conditioning, mice received either 25×106 KbDb−/− C57BL/6 (MHC I KO) (n=8) or 25×106 CD45.2 C57BL/6 (WT) (n=7) BM cells. Donor chimerism in the MAC-1 and the B cell lineage is depicted 6 weeks after BMT. Each symbol represents an individual animal. Lines indicate mean values. ***p=0.0003 with a Mann Whitney test.