Figure 5. Collection of the features used to define the pharmacophoric model for the binding of the triterpenes to the ABHD12.

Color coding of pharmacophoric features: green, hydrophobic site; magenta, acceptor site; cyan, donor site; gray cage, ligand shape constraint. B. The best solution for the alignment of the most active compound (33) to pharmacophore model (the same color coding as above except the ligand surface omitted for the clarity).