Table 1. Inhibitor potency in hABHD12-HEK293 lysates for commercially available triterpenes (1–11) and triterpenoids (12–15) as well as their calculated lipophilicity values (logD).

Compound	General name	Remaining activity at 10 µM % ± s.e.m.	-logIC50±s.e.m. [IC50] (max inhibition)	logD1 (pH 7.4)
1	Betulinic acid		5.60±0.182 [2.5 µM]	4.04
2	Betulin	∼75		6.17
3	Lupeol	NI		7.45
4	Ursolic acid	∼30	5.74±0.142 [1.8 µM]	3.98
5	Asiatic acid	NI		1.62
6	α-Amyrin	NI		7.39
7	Oleanolic acid	∼20	5.80±0.072 [1.6 µM]	3.99
8	Maslinic acid		5.90±0.04 [1.3 µM] (89%)	2.92
9	Hederagenin	78±3.0		2.71
10	β-Amyrin	NI		7.40
11	α-Boswellic acid	NI		3.84
12	CDDO	NI		3.68
13	CDDO methyl ester	NI		6.55
14	Celastrol	NI		2.75
15	Pristimerin	NI		5.47

¹logD values have been calculated using ChemAxon Marvin 6.0 software.

²Valueas are -logIC₅₀±s.d., n = 2.

NI no inhibition.

Data are mean ± SEM from three independent experiments.