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. Author manuscript; available in PMC: 2014 Jun 4.
Published in final edited form as: Birth Defects Res A Clin Mol Teratol. 2010 Feb;88(2):111–127. doi: 10.1002/bdra.20631

Table 4. Ion channel pathway.

A) Over and B) under expressed genes involved in the ion channel signaling pathway. Each column as described in Table 3.

Ion Channel Pathway
Over-Expressed
1 2 3 4 5 6 7
Sequence ID Gene ID Description 0 CTL v 0 TCE 2 CTL v 2 TCE 8 CTL v 8 TCE 2 TCE v 0 TCE 2 TCE v 8 TCE 2 CTL v 0 CTL 2 CTL v 8 CTL
NM_009781 Cacna1c calcium channel
NM_009783 Cacna1g calcium channel
NM_009784 Cacna2d1 calcium channel
NM_007582 Cacng1 calcium channel
BC051033 Fxyd3 FXYD domain-containing ion transport regulator 3
NM_146017 Gabrp gamma-aminobutyric acid receptor
ENSMUST76349 Gria3 glutamate receptor
NM_008170 Grin2a glutamate receptor
ENSMUST72602 Hvcn1 hydrogen voltage-gated channel 1
NM_010585 Itpr1 inositol 1
NM_019923 Itpr2 inositol 1
NM_010597 Kcnab1 potassium voltage-gated channel
NM_134110 Kcne2 potassium voltage-gated channel
NM_020574 Kcne3 potassium voltage-gated channel
NM_010603 Kcnj12 potassium inwardly-rectifying channel
ENSMUST46765 Kcnk1 potassium channel
NM_008431 Kcnk4 potassium channel
NM_023872 Kcnq5 potassium voltage-gated channel
NM_173417 Kcns3 potassium voltage-gated channel
ENSMUST39450 Mcoln3 mucolipin 3
NM_023868 Ryr2 ryanodine receptor 2
NM_001099298 Scn2a1 sodium channel
NM_153417 Trpm6 transient receptor potential cation channel
ENSMUST103224 Trpm7 transient receptor potential cation channel
NM_022413 Trpv6 transient receptor potential cation channel
Under-expressed
1 2 3 4 5 6 7
Sequence ID Gene ID Description 0 CTL v 0 TCE 2 CTL v 2 TCE 8 CTL v 8 TCE 2 TCE v 0 TCE 2 TCE v 8 TCE 2 CTL v 0 CTL 2 CTL v 8 CTL
ENSMUST49346 Accn3 amiloride-sensitive cation channel 3
NM_021415 Cacna1h calcium channel
NM_009784 Cacna2d1 calcium channel
NM_023116 Cacnb2 calcium channel
NM_001037099 Cacnb4 calcium channel
ENSMUST45706 Cftr cystic fibrosis transmembrane conductance regulator homolog
ENSMUST71697 Fxyd1 FXYD domain-containing ion transport regulator 1
BC031112 Fxyd5 FXYD domain-containing ion transport regulator 5
NM_008070 Gabrb2 gamma-aminobutyric acid (GABA-A) receptor
NM_146017 Gabrp gamma-aminobutyric acid (GABA-A) receptor
NM_019923 Itpr2 inositol 1
NM_145983 Kcna5 potassium voltage-gated channel
NM_008424 Kcne1 potassium voltage-gated channel
NM_020574 Kcne3 potassium voltage-gated channel
NM_010600 Kcnh1 potassium voltage-gated channel
NM_013569 Kcnh2 potassium voltage-gated channel
ENSMUST39366 Kcnh8 potassium voltage-gated channel
NM_145963 Kcnj14 potassium inwardly-rectifying channel
NM_010604 Kcnj16 potassium inwardly-rectifying channel
ENSMUST42970 Kcnj2 potassium inwardly-rectifying channel
NM_010605 Kcnj5 potassium inwardly-rectifying channel
NM_001033876 Kcnk9 potassium channel
NM_010610 Kcnma1 potassium large conductance calcium-activated channel
NM_031169 Kcnmb1 potassium large conductance calcium-activated channel
NM_080465 Kcnn2 potassium intermediate/small conductance calcium-activated channel
NM_023872 Kcnq5 potassium voltage-gated channel
ENSMUST22272 Kctd6 potassium channel tetramerisation domain containing 6
ENSMUST67951 Kctd9 potassium channel tetramerisation domain containing 9
ENSMUST23509 Klhl24 kelch-like 24 (Drosophila
ENSMUST39450 Mcoln3 mucolipin 3
NM_177755 Rik RIKEN cDNA 8230402K04 gene
NM_023868 Ryr2 ryanodine receptor 2
BC039140 Scn1b sodium channel
NM_001099298 Scn2a1 sodium channel
NM_018732 Scn3a sodium channel
NM_013838 Trpc6 transient receptor potential cation channel
ENSMUST103224 Trpm7 transient receptor potential cation channel
ENSMUST9036 Vdac3 voltage-dependent anion channel 3