Table 6. Apoptosis pathway.

A) Over and B) under expressed genes involved in the apoptosis pathway. Each column as described in Table 3.

Apoptosis Pathway
Over-expressed
			1	2	3	4	5	6	7
Sequence ID	Gene ID	Description	0 CTL v 0 TCE	2 CTL v 2 TCE	8 CTL v 8 TCE	2 TCE v 0 TCE	2 TCE v 8 TCE	2 CTL v 0 CTL	2 CTL v 8 CTL
ENSMUST103020	Aatk	apoptosis-associated tyrosine kinase
NM 007536	Bcl2a1d	B-cell leukemia/lymphoma 2 related protein A1d
ENSMUST115094	Birc4	baculoviral IAP repeat-containing 4
ENSMUST107228	Brca1	breast cancer 1
ENSMUST31895	Casp2	caspase 2
ENSMUST93517	Casp3	caspase 3
NM 001042605	Cd74	CD74 antigen (invariant polypeptide of major histocompatibility complex
ENSMUST46506	Clcf1	cardiotrophin-like cytokine factor 1
ENSMUST53594	Cradd	CASP2 and RIPK1 domain containing adaptor with death domain
ENSMUST31697	Cul1	cullin 1
BC092213	Cycs	cytochrome c
ENSMUST26475	Ddit3	DNA-damage inducible transcript 3
ENSMUST37907	Ddx58	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
ENSMUST84488	Dock1	dedicator of cyto-kinesis 1
ENSMUST39516	Egln3	EGL nine homolog 3 (C. elegans)
ENSMUST27066	Eya1	eyes absent 1 homolog (Drosophila)
ENSMUST25691	Fas	Fas (TNF receptor superfamily member 6)
NM 010185	Fcer1g	Fc receptor
BC048734	Fgf8	fibroblast growth factor 8
ENSMUST57884	Gps2	G protein pathway suppressor 2
ENSMUST23507	Gsk3b	glycogen synthase kinase 3 beta
ENSMUST30683	Hgf	hepatocyte growth factor
ENSMUST38777	Hipk2	homeodomain interacting protein kinase 2
NM 010478	Hspa1b	heat shock protein 1B
NM 010414	Htt	huntingtin
ENSMUST20702	Igfbp3	insulin-like growth factor binding protein 3
ENSMUST102786	Itgb3bp	integrin beta 3 binding protein (beta3-endonexin)
ENSMUST49248	Malt1	mucosa associated lymphoid tissue lymphoma translocation gene 1
ENSMUST95806	Map3k5	mitogen activated protein kinase kinase kinase 5
ENSMUST67429	Mdm4	transformed mouse 3T3 cell double minute 4
AK018196	Mitf	microphthalmia-associated transcription factor
ENSMUST28288	Notch1	Notch gene homolog 1 (Drosophila)
ENSMUST30154	Nudt2	nudix (nucleoside diphosphate linked moiety X)-type motif 2
ENSMUST51209	Peg3	paternally expressed 3
ENSMUST32573	Pglyrp1	peptidoglycan recognition protein 1
NM 001077495	Pik3r1	phosphatidylinositol 3-kinase
NM 011159	Prkdc	protein kinase
AK083198	Prlr	prolactin receptor
ENSMUST59507	Purb	purine rich element binding protein B
ENSMUST6851	Qrich1	glutamine-rich 1
ENSMUST22034	Rasa1	RAS p21 protein activator 1
NM 011279	Rnf7	ring finger protein 7
ENSMUST115866	Rock1	Rho-associated coiled-coil containing protein kinase 1
ENSMUST102843	Rtn4	reticulon 4
ENSMUST101118	Rybp	RING1 and YY1 binding protein
NM 001099298	Scn2a1	sodium channel
ENSMUST21728	Siva1	SIVA1
NM 011434	Sod1	superoxide dismutase 1
ENSMUST49931	Spn	sialophorin
ENSMUST112747	Spp1	secreted phosphoprotein 1
XM 915205	Syngap1	synaptic Ras GTPase activating protein 1 homolog
ENSMUST45288	Tgfb2	transforming growth factor
ENSMUST95753	Tia1	cytotoxic granule-associated RNA binding protein 1
NM 178931	Tnfrsf14	tumor necrosis factor receptor superfamily
NM 026654	Toe1	target of EGR1
AF357400	Tpt1	tumor protein
ENSMUST40312	Trib3	tribbles homolog 3 (Drosophila)
AB020317	Trp53	transformation related protein 53
ENSMUST40231	Trp63	transformation related protein 63
ENSMUST106236	Unc5c	unc-5 homolog C (C. elegans)
ENSMUST71648	Vegfa	vascular endothelial growth factor A
ENSMUST21937	Zfp346	zinc finger protein 346

Under-expressed
			1	2	3	4	5	6	7
Sequence ID	Gene ID	Description	0 CTL v 0 TCE	2 CTL v 2 TCE	8 CTL v 8 TCE	2 TCE v 0 TCE	2 TCE v 8 TCE	2 CTL v 0 CTL	2 CTL v 8 CTL
NM 001033369	Acvr1c	activin A receptor
ENSMUST109749	Akt1	thymoma viral proto-oncogene 1
NM 013467	Aldh1a1	aldehyde dehydrogenase family 1
ENSMUST329	Alox12	arachidonate 12-lipoxygenase
NM 009686	Apbb2	amyloid beta (A4) precursor protein-binding
ENSMUST6828	Aplp1	amyloid beta (A4) precursor-like protein 1
ENSMUST3066	Apoe	apolipoprotein E
ENSMUST96119	Asah2	N-acylsphingosine amidohydrolase 2
NM 022305	B4galt1	UDP-Gal:betaGlcNAc beta 1
ENSMUST108089	Bag1	Bcl2-associated athanogene 1
ENSMUST54636	Bag5	BCL2-associated athanogene 5
ENSMUST33093	Bax	Bcl2-associated X protein
ENSMUST2091	Bcap31	B-cell receptor-associated protein 31
ENSMUST29842	Bcl10	B-cell leukemia/lymphoma 10
ENSMUST66460	Bcl2a1c	B-cell leukemia/lymphoma 2 related protein A1c
ENSMUST22806	Bcl2l2	Bcl2-like 2
ENSMUST115094	Birc4	baculoviral IAP repeat-containing 4
NM 172149	Bnip1	BCL2/adenovirus E1B interacting protein 1
NM 009760	Bnip3	BCL2/adenovirus E1B interacting protein 1
ENSMUST27499	Bok	Bcl-2-related ovarian killer protein
NM 175362	Card11	caspase recruitment domain family
ENSMUST93517	Casp3	caspase 3
ENSMUST29626	Casp6	caspase 6
ENSMUST26062	Casp7	caspase 7
BC055070	Ccl2	chemokine (C-C motif) ligand 2
NM 001042605	Cd74	CD74 antigen (invariant polypeptide of major histocompatibility complex
ENSMUST23829	Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)
NM 009883	Cebpb	CCAAT/enhancer binding protein
ENSMUST34233	Ciapin1	cytokine induced apoptosis inhibitor 1
NM 007702	Cidea	cell death-inducing DNA fragmentation factor
ENSMUST59091	Clca1	chloride channel calcium activated 1
NM 025680	Ctnnbl1	catenin
BC092213	Cycs	cytochrome c
ENSMUST111530	Dad1	defender against cell death 1
NM 022994	Dap3	death associated protein 3
ENSMUST37907	Ddx58	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
BC024780	Diablo	diablo homolog (Drosophila)
ENSMUST103145	E2f1	E2F transcription factor 1
ENSMUST55990	Eef1a2	eukaryotic translation elongation factor 1 alpha 2
ENSMUST1757	Eef1e1	eukaryotic translation elongation factor 1 epsilon 1
ENSMUST39516	Egln3	EGL nine homolog 3 (C. elegans)
ENSMUST27066	Eya1	eyes absent 1 homolog (Drosophila)
ENSMUST33394	Fadd	Fas (TNFRSF6)-associated via death domain
ENSMUST35038	Faim	Fas apoptotic inhibitory molecule
ENSMUST25691	Fas	Fas (TNF receptor superfamily member 6)
ENSMUST73152	Fastkd1	FAST kinase domains 1
ENSMUST27103	Fastkd2	FAST kinase domains 2
ENSMUST19198	Fis1	fission 1 (mitochondrial outer membrane) homolog (yeast)
ENSMUST75491	Fkbp8	FK506 binding protein 8
ENSMUST15456	Gadd45b	growth arrest and DNA-damage-inducible 45 beta
NM 010295	Gclc	glutamate-cysteine ligase
NM 008129	Gclm	glutamate-cysteine ligase
AK005055	Glo1	glyoxalase 1
ENSMUST82429	Gpx1	glutathione peroxidase 1
XM_001478151	Hbxip	hepatitis B virus × interacting protein
ENSMUST28600	Hipk3	homeodomain interacting protein kinase 3
ENSMUST26572	Hras1	Harvey rat sarcoma virus oncogene 1
NM 010478	Hspa1b	heat shock protein 1B
ENSMUST89645	Htra2	HtrA serine peptidase 2
ENSMUST20702	Igfbp3	insulin-like growth factor binding protein 3
ENSMUST889	Il4	interleukin 4
ENSMUST102786	Itgb3bp	integrin beta 3 binding protein (beta3-endonexin)
ENSMUST47616	Jmjd6	jumonji domain containing 6
ENSMUST65537	Jmy	junction-mediating and regulatory protein
NM 023788	Mageh1	melanoma antigen
AK018196	Mitf	microphthalmia-associated transcription factor
ENSMUST22971	Myc	myelocytomatosis oncogene
NM 144931	Nae1	NEDD8 activating enzyme E1 subunit 1
NM 023312	Ndufa13	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex
ENSMUST5647	Ndufs3	NADH dehydrogenase (ubiquinone) Fe-S protein 3
NM 010910	Nefl	neurofilament
ENSMUST53540	Ngfrap1	nerve growth factor receptor (TNFRSF16) associated protein 1
ENSMUST28288	Notch1	Notch gene homolog 1 (Drosophila)
ENSMUST23779	Nr4a1	nuclear receptor subfamily 4
ENSMUST21284	Ntn1	netrin 1
NM 028778	Nuak2	NUAK family
ENSMUST30154	Nudt2	nudix (nucleoside diphosphate linked moiety X)-type motif 2
ENSMUST57195	Nup62	nucleoporin 62
NM 001081170	Pacs2	phosphofurin acidic cluster sorting protein 2
ENSMUST29424	Pdcd10	programmed cell death 10
ENSMUST32577	Pdcd5	programmed cell death 5
ENSMUST22060	Pdcd6	programmed cell death 6
ENSMUST27247	Pdcl3	phosducin-like 3
NM 022032	Perp	PERP
NM 009344	Phlda1	pleckstrin homology-like domain
ENSMUST34296	Pik3r2	phosphatidylinositol 3-kinase
ENSMUST98513	Plekhf1	pleckstrin homology domain containing
ENSMUST14578	Plg	plasminogen
ENSMUST33938	Polb	polymerase (DNA directed)
ENSMUST27373	Ppm1f	protein phosphatase 1F (PP2C domain containing)
NM 001010836	Ppp1r13l	protein phosphatase 1
BC002034	Prdx2	peroxiredoxin 2
NM 011159	Prkdc	protein kinase
NM 011871	Prkra	protein kinase
ENSMUST59507	Purb	purine rich element binding protein B
ENSMUST27040	Rb1cc1	RB1-inducible coiled-coil 1
NM 007483	Rhob	ras homolog gene family
NM 026443	Rik	RIKEN cDNA 1700020C11 gene
BC051541	Rik	RIKEN cDNA 2600009E05 gene
BC025611	Ripk2	receptor (TNFRSF)-interacting serine-threonine kinase 2
NM 019955	Ripk3	receptor-interacting serine-threonine kinase 3
AK220529	Rnf130	ring finger protein 130
NM 011279	Rnf7	ring finger protein 7
ENSMUST30399	Rragc	Ras-related GTP binding C
ENSMUST101118	Rybp	RING1 and YY1 binding protein
ENSMUST78481	Scin	scinderin
NM 001099298	Scn2a1	sodium channel
ENSMUST21728	Siva1	SIVA1
NM 026404	Slc35a4	solute carrier family 35
ENSMUST25997	Smndc1	survival motor neuron domain containing 1
ENSMUST56150	Snrk	SNF related kinase
ENSMUST102774	Sqstm1	sequestosome 1
ENSMUST27263	Stk17b	serine/threonine kinase 17b (apoptosis-inducing)
ENSMUST88585	Sulf1	sulfatase 1
XM 915205	Syngap 1	synaptic Ras GTPase activating protein 1 homolog (rat)
ENSMUST18407	Tbx5	T-box 5
NM 025780	Thap2	THAP domain containing
NM 153552	Thoc1	THO complex 1
ENSMUST102793	Tm2d1	TM2 domain containing 1
ENSMUST19997	Tnfaip3	tumor necrosis factor
NM 134131	Tnfaip8	tumor necrosis factor
NM 011609	Tnfrsf1a	tumor necrosis factor receptor superfamily
NM 026654	Toe1	target of EGR1
ENSMUST21471	Txndc1	thioredoxin domain containing 1
ENSMUST50183	Uaca	uveal autoantigen with coiled-coil domains and ankyrin repeats