Table II. Survival and toxicity measures for different schedules of oxaliplatin thermochemotherap.

Survival and toxicity measures from two experiments for different schedules of oxaliplatin thermochemotherapy: average median survival, percent cures, maximum body weight loss, and decrease in hematocrit to nadir for rats treated with fever-range whole body thermal therapy before, simultaneously with, and after oxaliplatin. The doseof oxaliplatin was either 10 mg/kg or 12 mg/kg.

Group/Schedule	Median survival (days)	Cured %)	Maximum body weight loss (%)	Decrease in hematocrit to nadir (%)
Untreated controls1,2	23, 27	0	14.1, 15.2	29.01
FR-WB-TT1	27	0	14.2	22.9
OX + FR-WB-TT simultaneously1	28	0	12.2	22.0
Oxaliplatin (10 mg/kg)2	29.5	17	12.5
Oxaliplatin (12 mg/kg)1	31.5	0	9.9§	13.2
Oxaliplatin 3h before FR-WB-TT2	28	0	13.5
Oxaliplatin 12h before FR-WB-TT2	225§	50	5.6§§§,*
OX 24h before FR-WB-TT(10 mg/kg)2	309.5§,*	50	6.0§§§,*
OX 24h before FR-WB-TT(12 mg/kg)1	37§	17	7.9§§§,*	4.2§§, **
OX 24h after FR-WB-TT1	28.5	0	15.2	8.2§,*

Data presented from two experiments:

¹experiment 1, 12 mg/kg oxaliplatin;

²experiment 2, 10 mg.kg oxaliplatin

^§p < 0.05,

^§§p < 0.001,

^§§§ p < 0.0001 vs. control;

^*p < 0.05;

^**p < 0.01 vs. OX alone