Table 2.

Incidence of most common (≥10 %) and all severe AEs related to BIIB022

	Toxicity grade					Total
	1	2	3	4	5
Headache	18 (53 %)	2 (6 %)	0	0	0	20 (59 %)
Fatigue	4 (12 %)	5 (15 %)	1 (3 %)	0	0	10 (29 %)
Dizziness	2 (6 %)	3 (9 %)	0	0	0	5 (15 %)
Nausea	4 (12 %)	1 (3 %)	0	0	0	5 (15 %)
Muscle spasms	2 (6 %)	3 (9 %)	0	0	0	5 (15 %)
Hypertension	0	1 (3 %)	1 (3 %)	0	0	2 (6 %)
Dyspnea	0	1 (3 %)	1 (3 %)	0	0	2 (6 %)
asthenia	1 (3 %)	0	1 (3 %)	0	0	2 (6 %)
Gastrointestinal hemorrhage	0	0	1 (3 %)	0	0	1 (3 %)
Deep vein thrombosis	0	0	1 (3 %)	0	0	1 (3 %)
Prolonged QTc interval	0	0	1 (3 %)	0	0	1 (3 %)