Table 5.
Pharmacokinetic parameters
| Pharmacokinetic parametera | BIIB022 dose (mg/kg) | ||||
|---|---|---|---|---|---|
| 1.5 (N = 4) | 5 (N = 3) | 10 (N = 3) | 20 (N = 6) | 30 (N = 18) | |
| Cmax (μg/mL) | 29.8 ± 6.13 | 82.6 ± 7.13 | 172 ± 70.7 | 412 ± 78.2 | 801 ± 48.0 |
| AUCinf (dayaμg/mL) | 164 ± 45.3 | 559 ± 166 | 2160 ± 1260 | 5610 ± 2260 | 9330 ± 2310 |
| CL (L/day) | 0.686 ± 0.107 | 0.734 ± 0.267 | 0.327 ± 0.078 | 0.268 ± 0.108 | 0.262 ± 0.085 |
| t1/2 (day) | 4.72 ± 0.401 | 5.12 ± 2.01 | 13.7 ± 5.24 | 15.2 ± 6.64 | 15.4 ± 5.71 |
| Vss (L) | 4.18 ± 0.519 | 5.37 ± 1.03 | 6.00 ± 1.36 | 4.94 ± 0.221 | 5.34 ± 2.23 |
aData presented are the mean ± standard deviation from dose 1 only
C max maximum-observed serum concentration, AUC area-under-the concentration time curve, CL clearance, t 1/2 terminal half-life, V ss volume of distribution at steady-state