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. 2014 Apr;25(100):57–66. doi: 10.1016/j.sbi.2013.12.002

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© 2014 The Authors

This is an open access article under the CC BY-NC-SA license (http://creativecommons.org/licenses/by-nc-sa/3.0/).

PMC Copyright notice

Crystal structures of the Brr2 helicase [10^•,11^••,12^••]. (a) RNA interaction network in pre-catalytic and activated spliceosomes. Extensively based-paired U4/U6 snRNA duplex undergoes remodelling by the action of Brr2 helicase leading to the formation of the catalytically active secondary structures in the U6 snRNA. Adapted from [2]. (b) Schematic representation of the domain organizations of Brr2. Domains are colour coded: pink, N-terminal extension; light grey, RecA1; dark grey, RecA2; blue: winged-helix (WH); cyan, ratchet; yellow, helix-loop-helix (HLH) and orange, fibronectin3-like (FN3). (c) Overall structure of Brr2:Jab1/MPN complex. The structural domains are coloured as in (a) and labelled with N- and C- to indicate which helicase cassette they belong to.