Table 4.
Mutagen-related Compounds, ORs and 95% CIs for Specific Mutagen by Meat Subtype1
| Variable | Cases (n=1062) N(%)2 |
Controls (n=1645) N(%)2 |
OR (95% CI)3 | Ptrend4 |
|---|---|---|---|---|
| Total MeIQx | ||||
| Daily Intake (ng/day) (Mean,SD) | 75.4 (163.3) | 53.5 (101.3) | <0.0001 | |
| Quartile 15 | 168 (16.7) | 401 (25.0) | 1.00 | |
| Quartile 2 | 188 (18.7) | 401 (25.0) | 1.09 (0.84,1.42) | |
| Quartile 3 | 289 (28.7) | 401 (25.0) | 1.47 (1.14,1.90) | |
| Quartile 4 | 361 (35.9) | 401 (25.0) | 1.87 (1.44,2.44) | |
| Red Meat MeIQx | ||||
| Daily Intake (ng/day) (Mean,SD) | 72.2 (162.3) | 50.5 (96.7) | <0.0001 | |
| Quartile 15 | 165 (16.6) | 393 (25.0) | 1.00 | |
| Quartile 2 | 190 (19.1) | 394 (25.0) | 1.12 (0.86,1.47) | |
| Quartile 3 | 273 (27.4) | 394 (25.0) | 1.47 (1.13,1.91) | |
| Quartile 4 | 369 (37.0) | 393 (25.0) | 2.04 (1.55,2.68) | |
| White Meat MeIQx | ||||
| Daily Intake (ng/day) (Mean,SD) | 3.9 (7.0) | 4.0 (8.4) | 0.34 | |
| Quartile 15 | 230 (23.3) | 400 (25.4) | 1.00 | |
| Quartile 2 | 248 (25.1) | 378 (24.0) | 1.15 (0.89,1.48) | |
| Quartile 3 | 246 (24.9) | 403 (25.6) | 0.96 (0.75,1.24) | |
| Quartile 4 | 265 (26.8) | 393 (25.0) | 0.97 (0.74,1.26) | |
| Total PhIP | ||||
| Daily Intake (ng/day) (Mean,SD) | 187.3 (318.7) | 169.8 (412.5) | 0.18 | |
| Quartile 15 | 223 (22.2) | 401 (25.0) | 1.00 | |
| Quartile 2 | 225 (22.4) | 401 (25.0) | 0.95 (0.74,1.23) | |
| Quartile 3 | 268 (26.6) | 401 (25.0) | 1.08 (0.84,1.39) | |
| Quartile 4 | 290 (28.8) | 401 (25.0) | 1.18 (0.91,1.52) | |
| Red Meat PhIP | ||||
| Daily Intake (ng/day) (Mean,SD) | 93.3 (192.5) | 71.3 (205.3) | 0.009 | |
| Quartile 15 | 204 (20.5) | 394 (25.0) | 1.00 | |
| Quartile 2 | 230 (23.1) | 393 (25.0) | 1.07 (0.83,1.38) | |
| Quartile 3 | 235 (23.6) | 393 (25.0) | 0.99 (0.76,1.29) | |
| Quartile 4 | 328 (32.9) | 394 (25.0) | 1.38 (1.06,1.80) | |
| White Meat PhIP | ||||
| Daily Intake (ng/day) (Mean,SD) | 96.5 (184.3) | 101.7 (243.6) | 0.18 | |
| Quartile 15 | 271 (27.4) | 394 (25.0) | 1.00 | |
| Quartile 2 | 231 (23.4) | 401 (25.5) | 0.85 (0.67,1.09) | |
| Quartile 3 | 242 (24.5) | 385 (24.5) | 0.92 (0.72,1.19) | |
| Quartile 4 | 245 (24.8) | 394 (25.0) | 0.86 (0.67,1.11) | |
| Total DiMeIQx | ||||
| Daily Intake (ng/day) (Mean,SD) | 4.1 (7.8) | 3.1 (6.3) | 0.001 | |
| Quartile 15 | 174 (17.3) | 399 (24.9) | 1.00 | |
| Quartile 2 | 216 (21.5) | 403 (25.1) | 1.11 (0.86,1.45) | |
| Quartile 3 | 265 (26.6) | 393 (25.0) | 1.36 (1.05,1.75) | |
| Quartile 4 | 339 (34.0) | 394 (25.0) | 1.67 (1.29,2.17) | |
| White Meat DiMeIQx6 | ||||
| Daily Intake (ng/day) (Mean,SD) | 0.2 (0.7) | 0.2 (0.6) | 0.20 | |
| Total BaP | ||||
| Daily Intake (ng/day) (Mean,SD) | 39.6 (69.1) | 40.7 (84.3) | 0.47 | |
| Quartile 15 | 263 (26.1) | 401 (25.0) | 1.00 | |
| Quartile 2 | 255 (25.4) | 401 (25.0) | 1.00 (0.78,1.27) | |
| Quartile 3 | 238 (23.7) | 401 (25.0) | 0.87 (0.68,1.11) | |
| Quartile 4 | 250 (24.9) | 401 (25.0) | 0.87 (0.68,1.12) | |
| Red Meat BaP | ||||
| Daily Intake (ng/day) (Mean,SD) | 25.4 (50.4) | 22.2 (50.3) | 0.26 | |
| Quartile 15 | 256 (25.7) | 394 (25.0) | 1.00 | |
| Quartile 2 | 242 (24.3) | 393 (25.0) | 1.04 (0.81,1.33) | |
| Quartile 3 | 196 (19.7) | 393 (25.0) | 0.87 (0.67,1.12) | |
| Quartile 4 | 303 (30.4) | 394 (25.0) | 1.09 (0.85,1.40) | |
| White Meat BaP | ||||
| Daily Intake (ng/day) (Mean,SD) | 14.7 (44.7) | 19.3 (49.5) | 0.05 | |
| Quartile 15 | 268 (27.1) | 394 (25.0) | 1.00 | |
| Quartile 2 | 280 (28.3) | 393 (25.0) | 0.99 (0.78,1.26) | |
| Quartile 3 | 228 (23.1) | 394 (25.0) | 0.90 (0.70,1.16) | |
| Quartile 4 | 213 (21.5) | 393 (25.0) | 0.80 (0.62,1.04) | |
Because of missing data on mutagen intake the following were excluded from all analyses in this table: for total mutagen estimates 56 cases and 41 controls; for red meat-derived mutagen estimates 65 cases and 71 controls; for white meat-derived mutagen estimates 73 cases and 71 controls.
Values are N(%) unless otherwise notated.
ORs (95% CI) adjusted by unconditional logistic regression for age, sex, race, WHR, average daily total caloric intake, family history of colorectal cancer, smoking status and ever regular NSAID use. For each individual mutagen derived from a meat type (red or white meat), the opposite meat type for the individual mutagen was included as an adjusting variable (e.g., for Red Meat MeIQx, white meat MeIQx was included as adjusting variable).
Ptrend is for continuous variable
Referent
Because of too many zero values, quartiles were not generated for White Meat DiMeIQx.