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. 2014 Jan 21;2014:714081. doi: 10.1155/2014/714081

Figure 1.

Figure 1

Mesangial cells do not produce IL-6 upon stimulation with hyaluronan. TLR2-deficient (a), TLR4-deficient (b), and wild type (c) mesangial cells were exposed to hyaluronan of different sizes and concentrations as indicated. TLR2 and TLR4 agonists were used as positive controls for IL-6 induction. Additionally, wild type cells incubated with hyaluronan plus polymyxin B to exclude the influence of a random LPS-contamination. HA[S]: hyaluronan < 1500 Da; HA[L]: hyaluronan 1500 Da–3000 Da; PMB: polymyxin B; data are means ± SD, ns: not significant, *P ≤ 0.05–****P < 0.0001.