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Increased collagen expression in the diabetic heart. The db/db leptin receptor deficient mouse is a common model used to study the cardiovascular effects of type 2 diabetes. Picrosirus red staining of heart sections from control (A) and 12 week diabetic (B) mice illustrates the accumulation of collagen, as indicated by the bright red staining, which occurs in the diabetic heart. Scale bar = 50 µm.
