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. Author manuscript; available in PMC: 2014 Jun 4.
Published in final edited form as: BioDrugs. 2012 Aug 1;26(4):245–256. doi: 10.2165/11631680-000000000-00000

Fig. 1.

Fig. 1

Biologics in orthopedic surgery. The field of orthopedic surgery is currently using and investigating many different biologics with an aim of improving cell and tissue regeneration. The current gold standard is the bone autograft. Additional agents presented here are osteoconductive scaffolds, growth factors, cells, combination products, hormone therapy, and gene therapy. The current status of each product, whether it is used in basic science investigations, undergoing clinical trials, or US FDA approved for clinical usage, is denoted by red, blue, and green, respectively. BMP = bone morphogenetic protein; CPCs = calcium phosphate ceramics; DBM = demineralized bone matrix; MSCs = mesenchymal stromal cells; PRP = platelet-rich plasma.