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. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: Clin Immunol. 2013 Mar 26;148(1):44–55. doi: 10.1016/j.clim.2013.03.008

Figure 8. XRT-induced activation of NFκB pathway requires ATM, but not ROS in U937 cells.

Figure 8

Schematic of the mechanism of action for XRT-induced NFκB changes in U937 cells, in which XRT induced double-strand breaks, results in phosphorylation of ATM, and subsequent activation and phosphorylation of NEMO. ROS may also directly phosphorylate NEMO, but this would be a minor pathway.