Table 2.
Seizure-induced hippocampal cell death.
| Vaccination group | Number of rats examined | Hippocampal injury in CA1 and CA3 | |||
|---|---|---|---|---|---|
| (−) | (+) | (++) | (+++) | ||
| naïve | 7 | 2 | 2 | 1 | 2 |
| NR1[21–375] | 5 | 2 | 1 | 1 | 1 |
| NR1[313–619] | 6 | 1 | 0 | 2 | 3 |
| NR1[654–800] | 7 | 6* | 1 | 0 | 0 |
| Homer1a | 6 | 2 | 1 | 2 | 1 |
The brains of rats to reach stage 4 or beyond were analysed by TUNEL labeling. Hippocampal injury was graded as follows: (−) no injury; (+) minimal injury (1–20 TUNEL labelled cells); (++) moderate (21–100 TUNEL cells); (+++) high (>100 TUNEL cells). *P < 0.05compared to either Homer1a or naïve groups.