FIG. 8.

(A) Spleen from nontransgenic male showing normal white pulp (white arrows) and red pulp (black arrow), which appears normal although occasional megakaryocytes are identified, indicating a low degree of extramedullary hemopoiesis. (B) Spleen from a transgenic male. The red pulp is greatly expanded compared to the nontransgenic spleen in panel A and has largely replaced the white pulp. The red pulp contains a large amount of extramedullary hemopoiesis, including erythroid and myeloid elements and megakaryocytes. Magnification (A and B), ×100. (C) Liver from a nontransgenic male. Magnification, ×800. (D) Liver from a transgenic male (magnification, ×400), showing collections of monocytic cells, one of which is circled.